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Diss Factsheets
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EC number: 206-462-1 | CAS number: 345-78-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Based on skin (OECD 404) and eye irritation (OECD 405) studies performed in vivo, it can be concluded that the test substance is not corrosive or irritating to the skin and eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
In a skin irritation/corrosion test according to OECD guideline 404, 2 male and 1 female vienna white rabbit were dermally exposed to the test substance for 4 hours under semi-occlusive conditions (BASF 1986). Symptomes such as erythema (very slight to well-defined; all animals) and edema (very slight; two animals) were observed 4 hours after removal of the test substance. The mean value for erythema and for edema was 0 at the other time points (24, 48, 72 h). Based on the conditions of the performed skin irritation/corrosion test the substance is considered to be not irritating.
Eye irritation
The eye irritating potential of the test substance was examined in 2 male and 1 female Vienna White rabbits (OECD TG 405, no GLP). The animals were exposed to about 0.1 mL (37 mg) of test substance, and no rinsing of the eye was performed (BASF 1986). Observations were performed after 1, 24, 48, and 72 h. Conjunctivae redness (well-defined) and chemosis (slight) was observed in all 3 animals after 1h. The mean score (24 to 72 hours) for irritation was calculated to be 0.3, 0, and 0 for corneal opacity, 0, 0, and 0 for iritis, 0.7, 0.3, and 0 for conjunctivae redness, and 0.3, 0, and 0 for chemosis for animal 1, 2, and 3 respectively. Findings were reversible within 48 hours after application.
Justification for selection of skin irritation / corrosion endpoint:
One skin irritation / corrosion study is available. This study is adequate for covering this endpoint.
Justification for selection of eye irritation endpoint:
One eye irritation study is available. This study is adequate for covering this endpoint.
Justification for classification or non-classification
Based on the results obtained in the skin irritation test (according to OECD guideline 404) and the eye irritation test (according to OECD guideline 405) showing very limited effects, classification for skin irritation / corrosion and eye irritation is not warranted in accordance with EU Directive 67/548 (DSD) and EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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