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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013
Report date:
2013

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
Qualifier:
according to guideline
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
GLP compliance:
yes (incl. QA statement)
Test type:
acute toxic class method

Test material

Constituent 1
Chemical structure
Reference substance name:
N-phenylprop-2-enamide
EC Number:
606-936-1
Cas Number:
2210-24-4
Molecular formula:
C9 H9 N O
IUPAC Name:
N-phenylprop-2-enamide
Details on test material:
The administration volume was 10 mL/kg b.w..

Test animals

Species:
rat
Strain:
Crj: CD(SD)
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: 0.8% aqueous hydroxypropylmethylcellulose
Doses:
stepwise: 2000mg/kg, 300mg/kg
No. of animals per sex per dose:
3

Results and discussion

Effect levelsopen allclose all
Sex:
female
Dose descriptor:
other: NOEL
Effect level:
< 300 mg/kg bw
Sex:
female
Dose descriptor:
other: Dose level with first intolerance reactions
Effect level:
300 mg/kg bw
Sex:
female
Dose descriptor:
LDLo
Effect level:
2 000 mg/kg bw
Sex:
female
Dose descriptor:
LD50
Effect level:
>= 300 - <= 2 000 mg/kg bw
Sex:
female
Dose descriptor:
other: LD50 cut-off
Effect level:
500 mg/kg bw
Mortality:
During the 'single oral administration of 2000mg' study, all animals died prematurely within 3 hours.
During the 'single oral administration of 300mg' study, no premature death was recorded within the test period.
Clinical signs:
other: A single oral administration of 2000 mg CH03859/kg b.w. revealed reduced motility, ataxia, reduced muscle tone, dyspnoea and abdominal position in all 3 of 3 animals and tonic convulsion in one of 3 animals. A single oral administration of 300 mg CH03859/
Gross pathology:
No signs or abnormalities were noted at necropsy at both dose levels.

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Remarks:
Migrated information
Conclusions:
An OECD 423 acute oral toxicity study was performed for CH03859. The LD50 was between 300 and 2000 mg/kg bw. This leads to the following classification and labelling:
- 67/548/EEC : Xn, R22 harmful if swallowed
- (EC) 1272/2008: cat.4, H302 harmful if swallowed