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EC number: 251-882-0 | CAS number: 34206-40-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation / corrotion: Weight of evidence: Based on the read-across from two experimental studies (in-vivo skin irritation test with GLP) on analogue substance butan-2-one O,O',O''-(methylsilylidyne)trioxime, the read-across was applied and butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be non-irritant for skin of rabbits.
Eye irritation: Key study: Based on the read-across approach from experimental results (in-vivo eye irritation test with GLP) on analogue butan-2-one O,O',O''-(methylsilylidyne)trioxime, the substance butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be irritant to the eyes of rabbits.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
The analogue butan-2-one O,O',O''-(methylsilylidyne)trioxime which shares the same functional group with butan-2-one O,O',O'',O'''-silanetetrayltetraoxime, also has comparable values for the relevant molecular properties for skin irritation/corrosion.
See attached reporting format. - Reason / purpose for cross-reference:
- read-across source
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- (out of all 6 animals)
- Time point:
- 24/48/72 h
- Score:
- 0.11
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: (Erythema (Grade 1) in 2 of 6 animals. No further observations of erythema) (Results based on read-across from an analogue)
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- (out of all 6 animals)
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: (Results based on read-across from an analogue)
- Interpretation of results:
- not irritating
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Based on the read-across approach from experimental results on analogue butan-2-one O,O',O''-(methylsilylidyne)trioxime, the substance butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be non irritant to skin of rabbits.
- Executive summary:
An in-vivo skin irritaion test was performed on analogue substance butan-2-one O,O',O''-(methylsilylidyne)trioxime according to GLP. Mild, transient erythema was replaced by desquamation that remained in some animals the end of the short observation period (72 h). There was no oedema evident at any time point. The analogue substance was determined to be non-irritant for skin of rabbits. Based on these results, the read-across approach was applied and the substance butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was also determined to be non irritant to skin of rabbits.
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
The analogue butan-2-one O,O',O''-(methylsilylidyne)trioxime which shares the same functional group with butan-2-one O,O',O'',O'''-silanetetrayltetraoxime, also has comparable values for the relevant molecular properties for skin irritation/corrosion.
See attached reporting format. - Reason / purpose for cross-reference:
- read-across source
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Remarks:
- (out of all 6 animals)
- Time point:
- 24/48/72 h
- Score:
- 0.5
- Max. score:
- 8
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: (Results based on read-across from an analogue)
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1
- Reversibility:
- fully reversible within: 48 h
- Interpretation of results:
- not irritating
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Based on the read-across approach from experimental results on analogue butan-2-one O,O',O''-(methylsilylidyne)trioxime, the substance butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be non irritant to skin of rabbits.
- Executive summary:
An in-vivo skin irritaion test was performed on analogue substance butan-2-one O,O',O''-(methylsilylidyne)trioxime according to GLP. Transient effects to rabbit skin from 24-h occluded contact with the test material were observed. These effects were fully reversible within 48 h and thus the test substance was considered not to be irritant to the skin. Based on these results, the read-across approach was applied and the substance butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was also determined to be non irritant to skin of rabbits.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
The analogue butan-2-one O,O',O''-(methylsilylidyne)trioxime which shares the same functional group with butan-2-one O,O',O'',O'''-silanetetrayltetraoxime, also has comparable values for the relevant molecular properties for eye irritation/corrosion.
See attached reporting format. - Reason / purpose for cross-reference:
- read-across source
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- (out of all 6 animals)
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Remarks on result:
- other: (Results based on read-across from an analogue)
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- (out of all 6 animals)
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 2
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- other: (Results based on read-across from an analogue)
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- mean
- Remarks:
- (out of all 6 animals)
- Time point:
- 24/48/72 h
- Score:
- 0.6
- Max. score:
- 3
- Reversibility:
- fully reversible within: 4 days
- Remarks on result:
- other: (Results based on read-across from an analogue)
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- (out of all 6 animals)
- Time point:
- 24/48/72 h
- Score:
- 0.16
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: (Results based on read-across fron an analogue)
- Interpretation of results:
- irritating
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Based on the read-across approach from experimental results on analogue butan-2-one O,O',O''-(methylsilylidyne)trioxime, the substance butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be irritant to the eyes of rabbits.
- Executive summary:
An eye irritation/corrosion study was performed on the analogue substance butan-2-one O,O',O''-(methylsilylidyne)trioxime in a similar manner of OECD 405 and with GLP. The analogue substance was irritating to the eyes of rabbits since 4/6 animals had a mean (24, 48 and 72 hour) score ≥1 for corneal effects. Based on these results, the read-across approach was applied and the substance butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was also determined to be irritant to the eyes of rabbits.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation / Corrosion: Read-across from experimental data on analogue substance butan-2-one O,O',O''-(methylsilylidyne)trioxime:
Weight of evidence: An in-vivo skin irritaion test was performed on analogue substance butan-2-one O,O',O''-(methylsilylidyne)trioxime according to GLP. Transient effects to rabbit skin from 24-h occluded contact were observed. These effects were fully reversible within 48 h and thus the test substance was considered not to be irritant to the skin. Based on these results, the read-across approach was applied and the substance butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was also determined to be non-irritant to skin of rabbits.
Weight of evidence: An in-vivo skin irritaion test was performed on analogue substance butan-2-one O,O',O''-(methylsilylidyne)trioxime according to GLP. Mild, transient erythema was replaced by desquamation that remained in some animals at the end of the short observation period (72 h). There was no oedema evident at any time point. The analogue substance was determined to be non-irritant for skin of rabbits. Based on these results, the read-across approach was applied and the substance butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was also determined to be non irritant to skin of rabbits.
Eye irritation:Read-across from experimental data on analogue substance butan-2-one O,O',O''-(methylsilylidyne)trioxime:
Key study: An eye irritation/corrosion study was performed on the analogue substance butan-2-one O,O',O''-(methylsilylidyne)trioxime in a similar manner of OECD 405 and with GLP. The analogue substance was irritating to the eyes of rabbits since 4/6 animals had a mean (24, 48 and 72 hour) score ≥1 for corneal effects. Based on these results, the read-across approach was applied and the substance butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was also determined to be irritant to the eyes of rabbits.
Justification for selection of skin irritation / corrosion endpoint:
Weight of evident approach. Two studies are available with Klimisch score of two.
Justification for selection of eye irritation endpoint:
Only one study is available.
Effects on eye irritation: irritating
Justification for classification or non-classification
Skin irritation: Based on the available data, the substance is not classified as irritating according to CLP Regulation (EC) No 1272/2008.
Eye irritation: Based on the available data, the substance is classified as Irritating to eyes (category 2) according to CLP Regulation (EC) No 1272/2008 (cornea score >1, reversible effects).
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