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Environmental fate & pathways

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Biodegradation: The test substances was ready biodegradable

The biodegradability of MRD·92-436 and a positive control material (aniline) was studied in an aerobic, aqueous test system. This procedure was based on that outlined in the Organization for Economic Co-operation and Development (OECD) Test Guideline 301D, "Ready Biodegradability: Closed Bottle Test," (Reference 1). This procedure was used to determine biodegradability by measuring the amount of oxygen utilized by a microbial population during the oxidation of a test material added to a dosed test system.MRD·92-436 biodegraded to 78.8% after 28 days, using a test concentration of 2.10 mg/L.

Transport and distribution: Adsorption coefficient (Koc) of S-10793: log Koc was 1.30 (Koc= 20)

The HPLC method was performed at pH 7 as the test substance is a salt. The HPLC method using soil-adsorption-reference data was applied for the determination of the adsorption coefficient (Koc) of S-10793. The mobile phase was 30/70 (v/v) methanol/phosphate buffer pH 7. The column temperature was 35°C. In the HPLC chromatogram of the test solution, one major peak (99.6% peak area) and one small impurity peak (0.4% peak area) were observed. log Koc was 1.30 for the substance (Koc= 20) and < 1.26 for the impurity (Koc < 18). The study was performed in accordance with EC C.9 and OECD 121 and according to the principles of GLP.