Amines, C36-alkylenedi-

Endpoint summary

Key value for chemical safety assessment

Bioaccumulation potential:

no bioaccumulation potential

Additional information

Based on the physico-chemical properties of C36-alkylenediamine, low inhalation and oral bioavailability can be anticipated. The average molecular weight is about 500.

C36-alkylenediamine is insoluble in water and shows an extreme high calculated Log POW. The vapour pressure of all amines is very low.

Comparing results from full OECD 422 study in which males were dosed for 29 days and females for 43-57 days with results of the 14-day rangefinder, indicates there is no increase of toxicity symptoms with prolongation of dosing. This indicates the substance does not accumulate, and excretion is reasonably rapid.

 

From the profile information it is clear that the primary alkyl amine and the dimerdiamine structures show a very comparable profile. Both consist of primary amine and large apolar alkyl chain with some level of unsaturation, making it a surface active compound when protonated. Besides aliphatic chains and the primary amines there are no other functional groups. Consequently, the possible type of chemical reaction these substances are capable of will be principally similar. The primary amines groups are positively charged at environmental and physiological conditions (pH ≤ 8).

This cationic surfactant structure has a strong influence on the fate of these substances; they have high adsorptive properties to negatively charged surfaces e.g. particular matter under environmental conditions and to negatively charged cellular membranes. The apolar tails easily dissolve in the membranes, whereas the polar head causes disruption and leakage of the membranes leading to cell damage or lysis of the cell content. As a consequence, the whole molecule will not easily pass membrane structures. Consequently, these substances mainly cause direct effects at the area of contact. In agreement to this, the QSAR Toolbox only indicates mucous membrane irritation by aliphatic amines as a mechanism of toxicity relevant to human health, which specifically refers to reported effects in the stomach upon repeated oral dosing.

As a result of these properties, C36-alkylenediamine is not expected to be easily distributed over the body to exert its toxic activity over cells of other organs than those it came directly into contact with. Consequently, systemic activity can be expected to be low, and toxicity is driven by local effects related to the route of exposure and absorption.