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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Unsuitable test system for solid test substance

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report Date:
1973

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The test demonstrates the toxicity of an atmosphere saturated with dust of the test substance at 20 °C. Young adult laboratory rats, 12 females, were exposed to the dust generated by bubbling 200 L/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 8 h. No analytical determination of the atmosphere concentrations was performed. The nominal concentration was calculated as quotient of the amount of test substance weight loss during exposure, and the amount of air used during exposure. Group-wise documentation of clinical signs was performed over a 7 day study period. Body weight of groups was determined before the start of the study and at the end of the observation period.
GLP compliance:
no
Test type:
other: Inhalation hazard test

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
- Name of test material (as cited in study report): Sulfophthalsäure 24 Neutralsalz
- Physical state: solid
- Analytical purity: unknown (1,2-Benzenedicarboxylic acid, sulfo-, sodium salt with sodium sulfate)

Test animals

Species:
rat
Strain:
not specified
Sex:
female
Details on test animals and environmental conditions:
no data

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
not specified
Vehicle:
air
Details on inhalation exposure:
The test demonstrates the toxicity of an atmosphere saturated with dust of the test substance at 20 °C. Young adult laboratory rats, 12 females, were exposed to the dust generated by bubbling 200 L/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 8 h. No analytical determination of the atmosphere concentrations was performed. The nominal concentration was calculated as quotient of the amount of test substance weight loss during exposure, and the amount of air used during exposure. Group-wise documentation of clinical signs was performed over a 7 day study period. Body weight of groups was determined before the start of the study and at the end of the observation period.
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
Concentrations:
ca. 5.4 mg/l based on substance loss and air volume
No. of animals per sex per dose:
12 females
Control animals:
yes
Details on study design:
- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: not specified
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross pathology
Statistics:
N/A

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LC50
Effect level:
> 5.4 mg/L air (nominal)
Based on:
test mat.
Exp. duration:
8 h
Mortality:
no mortality occured
Clinical signs:
other: none
Body weight:
the animals gained weight normally
Gross pathology:
none

Applicant's summary and conclusion