Reaction mass of 1,2-Benzenedicarboxylic acid, 4-sulfo-, trisodium salt, 1,2-Benzenedicarboxylic acid, 3-sulfo-, sodium salt (1:3), Sodium sulphate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: Unsuitable test system for solid test substance

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1973

Report date:

1973

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The test demonstrates the toxicity of an atmosphere saturated with dust of the test substance at 20 °C. Young adult laboratory rats, 12 females, were exposed to the dust generated by bubbling 200 L/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 8 h. No analytical determination of the atmosphere concentrations was performed. The nominal concentration was calculated as quotient of the amount of test substance weight loss during exposure, and the amount of air used during exposure. Group-wise documentation of clinical signs was performed over a 7 day study period. Body weight of groups was determined before the start of the study and at the end of the observation period.

GLP compliance:

no

Test type:

other: Inhalation hazard test

Test material

Test material information

Constituent 1

Reference substance name:

1,2-Benzenedicarboxylic acid, sulfo-, sodium salt with sodium sulfate

IUPAC Name:

1,2-Benzenedicarboxylic acid, sulfo-, sodium salt with sodium sulfate

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Details on test material:

- Name of test material (as cited in study report): Sulfophthalsäure 24 Neutralsalz
- Physical state: solid
- Analytical purity: unknown (1,2-Benzenedicarboxylic acid, sulfo-, sodium salt with sodium sulfate)

Test animals

Species:

rat

Strain:

not specified

Sex:

female

Details on test animals or test system and environmental conditions:

no data

Administration / exposure

Route of administration:

inhalation: dust

Type of inhalation exposure:

not specified

Vehicle:

air

Details on inhalation exposure:

The test demonstrates the toxicity of an atmosphere saturated with dust of the test substance at 20 °C. Young adult laboratory rats, 12 females, were exposed to the dust generated by bubbling 200 L/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 8 h. No analytical determination of the atmosphere concentrations was performed. The nominal concentration was calculated as quotient of the amount of test substance weight loss during exposure, and the amount of air used during exposure. Group-wise documentation of clinical signs was performed over a 7 day study period. Body weight of groups was determined before the start of the study and at the end of the observation period.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

ca. 5.4 mg/l based on substance loss and air volume

No. of animals per sex per dose:

12 females

Control animals:

yes

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: not specified
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross pathology

Statistics:

N/A

Results and discussion

Effect levels

Sex:

female

Dose descriptor:

LC50

Effect level:

> 5.4 mg/L air (nominal)

Based on:

test mat.

Exp. duration:

8 h

Mortality:

no mortality occured

Clinical signs:

other: none

Body weight:

the animals gained weight normally

Gross pathology:

none