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Diss Factsheets
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EC number: 219-295-4 | CAS number: 2404-44-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian cell study: DNA damage and/or repair
- Remarks:
- Type of genotoxicity: DNA damage and/or repair
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1999
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No guideline study, well documented
Data source
Reference
- Reference Type:
- publication
- Title:
- Induction of unscheduled DNA synthesis in hairless mouse epidermis by skin carcinogens
- Author:
- Mori et al
- Year:
- 1 999
- Bibliographic source:
- J Tox Sci; Vol 24, 3, p.217-226
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Skin epidermis instead of liver cells were investigated for unscheduled DNA synthesis after topical application of the test item to mouse skin.
- GLP compliance:
- no
- Type of assay:
- unscheduled DNA synthesis
Test material
- Reference substance name:
- Decyloxirane
- EC Number:
- 220-667-3
- EC Name:
- Decyloxirane
- Cas Number:
- 2855-19-8
- Molecular formula:
- C12H24O
- IUPAC Name:
- 2-decyloxirane
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: HOS-HR1
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Food and water ad libitum. 12 h dark/light cycle.
Administration / exposure
- Route of administration:
- dermal
- Vehicle:
- acteone
- Details on exposure:
- before applying the test substance, the skin was stripped with a cellulose tape.
- Duration of treatment / exposure:
- 2 h
- Frequency of treatment:
- once
- Post exposure period:
- none
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
topical application
Basis:
nominal conc.
0.5%
- Remarks:
- Doses / Concentrations:
topical application
Basis:
nominal conc.
1%
- Remarks:
- Doses / Concentrations:
topical application
Basis:
nominal conc.
2%
- No. of animals per sex per dose:
- 5
- Control animals:
- yes, concurrent vehicle
- Positive control(s):
- yes
Examinations
- Tissues and cell types examined:
- skin epidermis
- Evaluation criteria:
- Ratio between DNS synthesis in presence and absence of hydroxy urea.
Results and discussion
Test results
- Sex:
- female
- Genotoxicity:
- negative
- Toxicity:
- not examined
- Vehicle controls validity:
- valid
- Negative controls validity:
- not examined
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
In this test system no unscheduled DNA synthesis was induced with the test item. - Executive summary:
In an adopted UDS assay, five mice received a single topical dose (0, 0.5, 1, 2%) of the test item. The skin epidermis was extracted and the unscheduled DNA synthesis was assessed using (3H)dTHd as marker. and a liquid scintillation counter as detector. No DNA synthesis was induced by the test item. The positive controls (DMBA, MNNG, BaP) were valid..
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