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Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Administrative data

Link to relevant study record(s)

Description of key information

The following study was used to address this endpoint:
Steger-Hartmann T (1999) Growth inhibition test of di-n-butyltin oxide (ZK 26385) on the green algae Scenedesmus subspicatus. Testing laboratory: Schering AG, Experimentelle Toxikologie, D-13342 Berlin, Germany. Owner company: Schering AG, Experimentelle Toxikologie, Berlin, Germany. Report No.: IC28. Company study No.: TXST19980234. Report date: 1999-02-17.
The study was performed to the guideline OECD 201, with a good level of reporting in the methodology and results. The study was assigned a reliability score of 2 as the study was performed on dibutyltin oxide, and read-across to the substance in question. Di-n-butyltin oxide had an inhibitory effect on the growth of the algae at all chosen concentrations. The inhibition was already observed after 24 hours. This was not concentration dependent and did not exceed 40% and 20 % for biomass integral and growth rate, even after 72 hours. The observed effects were not regarded as substance-related. The EC50 was given as >1.6 mg/L.

Key value for chemical safety assessment

Additional information

- Steger-Hartmann T (1999) studied the growth inhibition of di-n-butyltin oxide on the green algae Scenedesmus subspicatus. This study was allocated a reliability score of 2 and is the key study for this endpoint. Dibutyltin oxide was used to read across to dibutoxydibutylstannane. The study was performed to the OECD guideline 201. The EC50 of Scenedesmus subspicatus exposed to dibutyltin oxide was reported as >1.6 mg/L

Read-across between dibutyltin compounds to to dibutyl diacetate concerning aquatic toxicity endpoints was considered appropriate as dibutyltin and octyltins are known to hydrolyse rapidly in water (as presented by Yoder 2003, under the data requirement hydrolysis), and form, in the case of dibutyltins, dibutyltin oxide.

Key value for chemical safety assessment

EC50/LC50 for freshwater algae: >1.6 mg/L