Registration Dossier
Registration Dossier
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EC number: 405-400-2 | CAS number: 54253-62-2 KUPFER-II-METHANSULFONAT; KUPFERMETHANSULFONAT
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: study conducted by GLP accredited lab according to recognised guideline method. Data provided by ECHA from migrated NONS file. Litle detail available.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- Copper(II) methanesulfonate
- EC Number:
- 405-400-2
- EC Name:
- Copper(II) methanesulfonate
- Cas Number:
- 54253-62-2
- Molecular formula:
- C2H6CuO6S2
- IUPAC Name:
- copper(2+) dimethanesulfonate
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- water
- Doses:
- 750, 1040,1442,2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 110 mg/kg bw
- Based on:
- not specified
- 95% CL:
- >= 825 - <= 1 355
- Clinical signs:
- other: all animals showed hunched posture, lethargy, pilo-erection and decreased respiratory rate. Additional or isolated signs of toxicity noted were red/bronw staining around the snout, ataxia, pallor of the extremities, ptosis and occasionally body tremors. S
- Gross pathology:
- Abnormalities noted at necropsy if decedents included abnormally red lungs, dark diver of patchy pallor of the liver, dark kidneys, haemorrage of the glandular gastric epitelium and haemorrhage of the glandular gastric epithelium and haemorrage of the small intestine. No abnormalities were noted at the necropsy of animals killed at the end of the study except for an isolate incident of rights hydronephrosis.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance has an LD50 of 1100 mg/kg which means that the substance should be classified as Acute Tox. 4 according to CLP.
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