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Diss Factsheets
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EC number: 424-060-6 | CAS number: 6364-17-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Meets the criteria for classification as Reliable without restriction according to Klimisch et al (1997)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Version / remarks:
- 92/69/EEC
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
Test animals
- Species:
- other: Rat (Hsd:Sprague-Dawley(CD))
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Vehicle:
- other: 1% aqueous methylcellulose
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 211 mg/kg bw
- 95% CL:
- 175 - 253
- Remarks on result:
- other: Slope of the mortality curve: 11.4
- Mortality:
- Male: 250 mg/kg bw; Number of animals: 5; Number of deaths: 4
Female: 250 mg/kg bw; Number of animals: 5; Number of deaths: 4
Female: 200 mg/kg bw; Number of animals: 5; Number of deaths: 2
Female: 100 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- Signs of toxicity related to dose levels:
Two females at 200mg/kg and four males and four females at
250 mg/kg died during the study. All deaths occurred within
three days of dosing.
A slight bodyweight loss was recorded for the majority of
decedents.
Piloerection was observed in all rats within six minutes of
dosing. This sign persisted and was accompanied later on Day
1 and / or at later intervals during the study by hunched
posture, unsteady gait, and lethargy in all rats at all
dosages.
Respiratory distress was seen in all females at 200mg/kg and
in two males and two females at 25mg/kg.
Other signs of toxicity included partially closed eyelids,
soft to liquid faeces, increased salivation, cold body
surfaces and brown staining around the nose or mouth in rats
at one or more dose levels. - Gross pathology:
- Effects on organs:
Males and Females 250mg/kg
Congestion of the brain, heart, lungs and kidneys,
(characterised by dark appearance/prominent blood vessels
and inflammation), with congestion and atrophy of the
spleen. Congestion, fluid contents and gaseous distention
were noted in the stomach and along the alimentary tract
with fluid contents also observed in the urinary bladder.
Females 200mg/kg
Congestion of the subcutaneous tissue, brain, heart lungs
liver and kidneys were noted. Congestion, fluid contents and
gaseous distension of the stomach and along the alimentary
tract were noted and grey/black fluid contents also observed
in the urinary bladder.
No abnormalities were revealed at the macroscopic
examination of surviving animals on Day 15.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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