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EC number: 229-494-8 | CAS number: 6574-99-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- June 1981
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- There is no data available on skin irritation/corrosion testing with 3,4-Dichlorobenzonitrile. In order to classify the substance according to GHS relevant endpoint data available for 2,6-Dichlorobenzonitrile was read-acrossed to 3,4-Dichlorobenzonitrile based on structural similarities. 2,6-Dichlorobenzonitrile is as well as 3,4-Dichlorobenzonitrile, is a disubstituted Benzonitrile. Both substances only differ in the position of the chloro substituents. Furthermore both substances are solid, practically insoluble in water and have a water octanol partition coefficient of 2.2 and 2.8. This might perhaps also lead to a similiar skin irritation/corrosion potential of both substances.
for Justification of read across see section 13.2
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dichlobenil
- EC Number:
- 214-787-5
- EC Name:
- Dichlobenil
- Cas Number:
- 1194-65-6
- Molecular formula:
- C7H3Cl2N
- IUPAC Name:
- 2,6-dichlorobenzonitrile
- Details on test material:
- - Name of test material (as cited in study report): 2,6-Dichlorbenzonitril
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Russian White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: own breed
- Weight at study initiation: at least 2.5 and 2.8 kg
- Housing: during the post oberservation period the animals were housed in V2A-steelcages with a floor area of 0.4 m2.
- Diet (e.g. ad libitum): KF-G 774 of Laboratorium für Pharmakologie und Toxikologie, 2104 Hamburg 92, Germany) ad libitum
- Water (e.g. ad libitum): tap water ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 3 °C
- Humidity (%): 60 +/- 5 %
- Photoperiod (hrs dark / hrs light): 12 hours light (150 Lux), 12 hours dark
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 30-60 minutes and 24, 48, 72 and 96 hours after exposure
- Number of animals:
- 6 rabbits (3 male and 3 female)
- Details on study design:
- TEST SITE
- Area of exposure: max. 6 cm2 of the shaved dorsum skin
- Type of wrap if used: linen lobe with plastic film and bandage (Leukoplast, P. Beiersdorf & Co. AG, Unnastraße 48, 2000 Hamburg, Germany)
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data
- Time after start of exposure: 4 hours
SCORING SYSTEM:
Skin reaction erythema and eschar generation:
0: no erythema
1: very slight, barely perceptible erythema
2: distinctive erythema
3: moderate till serious erythema
4: serious (deep red) erythema till light eschar generation (serious damage)
skin reaction edema generation:
0: no edema
1: very slight, barely perceptible erythema
2: moderate edema with clear definition
3: moderate edema (swelling approx. 1 mm)
4: serious edema (swelling greater than 1 mm and overlapping the area of exposure)
Furthermore the appearance of necrosis was examined.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- 2,6-Dichlorobenzonitrile was tested to be not skin irritating in a test equivalent to OECD 404.
- Executive summary:
As there is no data available on skin irritation testing with 3,4 -Dichlorobenzonitrile relevant endpoint data available for 2,6 -Dichlorobenzonitrile was read-acrossed to 3,4 -Dichlorobenzonitrile in order to classify the substance (without any unecessary animal testing) according to GHS. The Read-Across approach was based on structrual and physico chemical similarities (see rational for reliablitity).
2,6 -Dichlorobenzontrile was tested to be not skin irritating in a test equivalent to OECD 404. This agrees with the non skin irritating property of 2 -Chlorobenzonitrile. Therefore 3,4 -Dichlorobenzonitrile was also classified as non irritating to skin.
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