Registration Dossier
Registration Dossier
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EC number: 248-440-4 | CAS number: 27394-99-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- only one dose tested (1000 mg/kg bw), animals were only observed for 7 days
- Principles of method if other than guideline:
- BASF-Test
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- N-(1-cyanoethyl)formamide
- EC Number:
- 248-440-4
- EC Name:
- N-(1-cyanoethyl)formamide
- Cas Number:
- 27394-99-6
- Molecular formula:
- C4H6N2O
- IUPAC Name:
- N-(1-cyanoethyl)formamide
- Details on test material:
- N-Formylalaninnitril (purity 98%)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 150 cm² - Duration of exposure:
- 24 h
- Doses:
- 1000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 days
- Statistics:
- not applicable
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 mg/kg bw
- Mortality:
- MORTALITY (after 1h, 24h, 48h, 7d):
Male animals: No dead animals.
Female animals: 2 animals were found dead after 24h. - Clinical signs:
- other: No symptoms and no local irritations were observed.
- Gross pathology:
- Dead animals: Heart: acute dilatation (right side); lung: hyperemia with edematization.
Sacrificed animals: No substance-related findings.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
