Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-702-7 | CAS number: 109-76-2
Respiratory sensitisation
Administrative data
- Endpoint:
- respiratory sensitisation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2003
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Trimethylenediamine is structural very similar to ethylenediamine (difference: chain length / one CH2-group). Therefore, the conclusions drawn, are sufficient for read across and assessment of the toxicity of trimethylenediamine.
Data source
Reference
- Reference Type:
- publication
- Title:
- OECD SIDS Ethylenediamine CASN°: 107-15-3
- Author:
- Anonymous
- Year:
- 2 003
- Bibliographic source:
- UNEP Publication
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- experience in humans with ethylenediamine (CAS# 107-15-3)
- GLP compliance:
- no
Test material
- Reference substance name:
- Ethylenediamine
- EC Number:
- 203-468-6
- EC Name:
- Ethylenediamine
- Cas Number:
- 107-15-3
- Molecular formula:
- C2H8N2
- IUPAC Name:
- ethane-1,2-diamine
Constituent 1
Test animals
- Species:
- human
- Strain:
- not specified
- Sex:
- not specified
Test system
- Route of induction exposure:
- inhalation
- Route of challenge exposure:
- inhalation
Results and discussion
- Results:
- According to the evaluations reported in "OECD SIDS Ethylenediamine CASN°: 107-15 -3" (2003), there are rare reports on cases of occupational sensitization in production facilities induced by ethylenediamine. Delayed-type asthma and occasionally dual-type asthma has been observed but no cases of immediate-type asthma were reported. Also the relationship between allergy symptoms and smoking practice on respiratory sensitization to ethylenediamine has been studied in employees of a manufacturing plant in USA. A subset of 38 individuals of 337 was identified by clinical and work history as having become sensitized to ethylenediamine showing symptoms like rhinitis, coughing and expiratory wheezing which cleared after removal from ethylenediamine work environment. Based on this information ethylenediamine is found to be a respiratory sensitizer in humans. Since trimethylenediamine is structurally very similar to ethylenediamine (difference: chain length / one CH2-group), it is assumed to be a respiratory sensitizer in humans.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
