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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2006-09-27 to 2007-04-18
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: A GLP study conducted according to OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method) and EU Method A8 (Partition Coefficient) without deviations.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2007
Report date:
2007

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Remarks:
The testing facility indicated that the protocol was followed without deviation.
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
Remarks:
The testing facility indicated that the protocol was followed without deviation.
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes (incl. QA statement)
Remarks:
Certificate from The Department of Health of the Government of the United Kingdom
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): VRT-126028
- Molecular formula (if other than submission substance): not applicable
- Molecular weight (if other than submission substance): not applicable
- Smiles notation (if other than submission substance): not applicable
- InChl (if other than submission substance): not applicable
- Structural formula attached as image file (if other than submission substance): not applicable
- Substance type: no data
- Physical state: white powder
- Analytical purity: 99.3 area% by Gas Chromatography (GC)
- Impurities: no data
- Composition of test material, percentage of components: no data
- Isomers composition: no data
- Purity test date: 2006-05-22
- Lot/batch No.: 25414
- Expiration date of the lot/batch: May 2008
- Stability under test conditions: no data
- Storage condition of test material: at room temperature
- Other: no data

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
2.7
Temp.:
25 °C
pH:
10
Details on results:
Mean calibration curve produced was: logPow = 4.52 logk + 3.33. A value of log10Pow for VRT-126028 of 2.7 was thus obtained. The oxalate counter-ion was not retained and eluted with the deadtime standard.

Any other information on results incl. tables

Mobile phase composition: Acetonitrile:pH 10 borate buffer (3:1 v/v). The mobile phase was buffered at pH 10 in order to examine the test substance in its non-ionised form. The pH of the mobile phase is completed in the result box of the 'Partition coefficient' above.

Applicant's summary and conclusion

Conclusions:
The test substance was found to have a logPow value of 2.7.
Executive summary:

Not applicable