Registration Dossier
Registration Dossier
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EC number: 608-681-1 | CAS number: 319-24-4
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP- and Guideline-Study with no or minor deficiencies.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- other: soil and sewage sludge
Test material
- Reference substance name:
- methyl 2-amino-5-fluorobenzoate
- EC Number:
- 608-681-1
- Cas Number:
- 319-24-4
- Molecular formula:
- C8 H8 F N O2
- IUPAC Name:
- methyl 2-amino-5-fluorobenzoate
Constituent 1
- Radiolabelling:
- no
Study design
HPLC method
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: HPLC-System Waters
- Type:
- Type, material and dimension of analytical (guard) column: Stainless steel, 250 mm, 4.6 mm ID, Luna 5µ CN, Phenomenex
- Detection system: Photodioden Array Detector 996 (Waters)
MOBILE PHASES
- Type: 55 % Methanol, 45 % Water
- Experiments with additives carried out on separate columns: no
- pH: no data
- Solutes for dissolving test and reference substances: Acetonitril/Water 1:1
DETERMINATION OF DEAD TIME
- Method: by inert substances (sodium nitrate) which are not retained by the column
REFERENCE SUBSTANCES
Identity:
2-Nitrobenzamide
N,N-dimethylbenzamide
4-Methylbenzamide
Atrazin
3-Nitrobenzamide
3,5-Dinitrobenzamide
Triadimenol
Naphthalene
1,2,3-Trichlorobenzene
Phenanthrene
4,4´-DDT
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: 140.4 mg/l
- Quantity of reference substances: 41.9-239.6 mg/l
REPETITIONS
- Number of determinations: 3
Results and discussion
Adsorption coefficient
- Type:
- log Koc
- Value:
- 2.3
- Remarks on result:
- other: Temperature not reported.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
