Registration Dossier
Registration Dossier
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EC number: 225-060-7 | CAS number: 4635-87-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- December 2001
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Version / remarks:
- December 2002
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EC No 440/2008 Part B. Acute Oral Toxicity, Acute Toxic Class Method
- Version / remarks:
- May 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Appendix to Director General Notification, No. 12-Nousan-8147. Agricultural Production Bureau, Ministry of Agriculture, Forestry and Fisheries of Japan (JMAFF), November 2000, including the most recent revisions
- Version / remarks:
- November 2000
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Pent-3-enenitrile
- EC Number:
- 225-060-7
- EC Name:
- Pent-3-enenitrile
- Cas Number:
- 4635-87-4
- Molecular formula:
- C5H7N
- IUPAC Name:
- (3E)-pent-3-enenitrile
- Details on test material:
- - Name of test material (as cited in study report): 3-Pentenenitrile
- Analytical purity: > 95 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Wistar Han
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- based on previous test results (Ac. Oral tox. 1981 ROND) male rats were known to be significantly more sensitive than females
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 50 and 300 mg/kg bw
- No. of animals per sex per dose:
- 3 males
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 50 - <= 300 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- male
- Dose descriptor:
- LD50 cut-off
- Effect level:
- 200 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 50 mg/kg bw: all 3 animals survived
300 mg/kg bw: all animals were found dead or sacrified in moribound condition between day 2 and 4 after treatment
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
