Registration Dossier
Registration Dossier
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EC number: 500-038-2 | CAS number: 25322-68-3 1 - 4.5 moles ethoxylated
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- experimental data for various test chemicals
- Justification for type of information:
- experimental data for various test chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: Refer the principle below
- Principles of method if other than guideline:
- WoE report is prepared based on toxicity to green algae study:
2 and 3 - GLP compliance:
- no
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- other: 3. Scenedesmus subspicatus 4. Scenedesmus quadricauda
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 96 h
- Remarks on exposure duration:
- for 3rd study period was 8 days.
- Reference substance (positive control):
- not specified
- Duration:
- 8 d
- Dose descriptor:
- EC50
- Effect conc.:
- 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: From study 3
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: From Study report 2
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The effect of test chemical was studied on the green algae the effective concentration range was determined to be 100 -1000 mg/L.
- Executive summary:
Short term toxicty for the test chemical are studied and mention as below:
The short-term toxicity of the test substance to green algae is studied using the RA , This study outlines the effect of test chemical on the Scenedesmus subspicatus. The study was performed on the in accordance with OECD guideline 201. The test was performed for the period 96 hours to observe the effects. Based on the results obtained the EC50 value was determined to >100 mg/L. According to the CLP classification the test chemical cannot be classified.
Similar study outlines the effect of test chemical on the Scenedesmus quadricauda. The test was performed for the period 8 days to observe the effects.
Based on the results obtained the 8d- EC50 value was determined to 1000mg/l. According to the CLP classification the test chemical is not classified.
Thus the toxicity is ranging from 100 to 1000mg/L
Reference
Description of key information
The short-term toxicity of the test substance to green algae is studied using the RA, This study outlines the effect of test chemical on the Scenedesmus subspicatus. The study was performed on the in accordance with OECD guideline 201. The test was performed for the period 96 hours to observe the effects.
Based on the results obtained the EC50 value was determined to >100 mg/L. According to the CLP classification the test chemical cannot be classified.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 100 mg/L
Additional information
Short term toxicity for the test chemical and structurally and functionally similar read across chemical are studied and mention as below:
The short-term toxicity of the test substance to green algae is studied using the RA, This study outlines the effect of test chemical on the Scenedesmus subspicatus. The study was performed on the in accordance with OECD guideline 201. The test was performed for the period 96 hours to observe the effects. Based on the results obtained the EC50 value was determined to >100 mg/L. According to the CLP classification the test chemical cannot be classified.
Similar study outlines the effect of test chemical on the Scenedesmus quadricauda. The test was performed for the period 8 days to observe the effects.
Based on the results obtained the 8d- EC50 value was determined to 1000mg/l.
According to the CLP classification the test chemical is not classified.
Thus the toxicity is ranging from 100 to 1000mg/L.
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