Registration Dossier
Registration Dossier
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EC number: 700-325-4 | CAS number: 1149346-12-2
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02 July - 21 July, 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study has been performed according to OECD and/or EC guidelines, and according to GLP principles.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Key result
- Water solubility:
- < 0.002 mg/L
- Temp.:
- 20.2 °C
- pH:
- ca. 7.2
- Details on results:
- At both flow rates no test substance was detected. Also, no test substance was detected in the samples from the blank column. After the test, the column was opened and the packing was analysed for test substance content and it was confirmed that test substance was still present on the column packing .Therefore, it can be concluded that the water solubility of HXL-8366 is < 1.89 x 10-6 g/l (i.e. < LOD).
- Conclusions:
- Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
The column elution method was chosen for the determination of the water solubility of HXL-8366. The water solubility of the test substance at 20.2 +/- 0.6°C was <1.89 x 10-6 g/l (i.e. < LOD). The mean pH of the aqueous samples was 7.2.
Reference
Description of key information
The water solubility of the test substance at 20.2 +/- 0.6°C was <1.89 x 10-6 g/l (i.e. < LOD).
Key value for chemical safety assessment
- Water solubility:
- 0 g/L
- at the temperature of:
- 20 °C
Additional information
The column elution method was chosen for the determination of the water solubility of HXL-8366. The water solubility of the test substance at 20.2 +/- 0.6 °C was <1.89 x 10-6 g/l (i.e. < LOD). The mean pH of the aqueous samples was 7.2.
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