Registration Dossier
Registration Dossier
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EC number: 248-107-3 | CAS number: 26919-50-6
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study results were published in a peer reviewed journal.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No information was provided to indicate specific guidelines.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Triethanolamine
- IUPAC Name:
- Triethanolamine
- Reference substance name:
- 2,2',2''-nitrilotriethanol
- EC Number:
- 203-049-8
- EC Name:
- 2,2',2''-nitrilotriethanol
- Cas Number:
- 102-71-6
- IUPAC Name:
- 2,2',2''-nitrilotriethanol
- Test material form:
- not specified
- Details on test material:
- Test Substance: Triethanolamine
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: Charles River CD rats
Administration / exposure
- Route of administration:
- dermal
- Vehicle:
- not specified
- Details on exposure:
- Application of semipermanent hair dye preparations (2 ml/kg) containing 0.1- 1.5% triethanolamine
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 19 days
- Frequency of treatment:
- Substance was administered on gestation days 1, 4, 7, 10, 13, 16, and 19
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.1 - 1.5%
Basis:
no data
- No. of animals per sex per dose:
- No data
Results and discussion
Results: maternal animals
Maternal developmental toxicity
- Details on maternal toxic effects:
- Maternal toxic effects:not examined
Effect levels (maternal animals)
- Basis for effect level:
- other: effect type not specified
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:no effects
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Any other information on results incl. tables
No embryotoxic or teratogenic effects were produced.
Applicant's summary and conclusion
- Conclusions:
- No embryotoxic or teratogenic effects were produced.
- Executive summary:
The developmental toxicity of the substance was determined via exposure of pregnant Charles River CD rats to preparations containing 0.1 - 1.5% triethanolamine by the dermal route. No embryotoxic or teratogenic effects were produced.
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