Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 237-913-0 | CAS number: 14064-10-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according EU/OECD guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Diethyl chloromalonate
- EC Number:
- 237-913-0
- EC Name:
- Diethyl chloromalonate
- Cas Number:
- 14064-10-9
- Molecular formula:
- C7H11ClO4
- IUPAC Name:
- 1,3-diethyl 2-chloropropanedioate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 200 and 2000 mg/kg body weight (bw)
- No. of animals per sex per dose:
- 3 male-, 3 female rats
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - < 500 mg/kg bw
Any other information on results incl. tables
A dose of 200 mg/kg body weight was tolerated by male rats without mortalities, clinical signs, effects on weight development and gross pathological findings. In females of the 200 mg/kg dose group the motility was decreased, breathing labored, and diarrhea and lateral position were observed. Additionally to the signs described, at 2,000 mg/kg piloerection, decreased reactivity, uncoordinated gait, narrowed palpebral fissures, and abdominal position, and in one female each, temporary tonical cramps and spasmodic state were detected. The signs observed started 2 hours after administration and lasted up to day 3. All females of the 2,000 mg/kg dose group and one female of the 200 mg/kg dose group died.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
