Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 610-122-1 | CAS number: 433733-94-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- Jan 2020
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- The prediction was considered satisfactory because of its chemical and structural similarity as well as the similar mechanisms of toxicity between the target chemical and the analogs.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The chemical was entered in the QSAR Toolbox by SMILES. The identified structure of the chemical was
retained and subsequently added to the data matrix. After selecting the endpoint of interest (acute
toxicity), in the data module, the relevant databases were searched for experimental data. No
experimental data was available. The profiling module was used to identify the main characteristics of
the chemical. In category definition, the chemical profiler (US EPA New chemical categories) was used to
categorize the chemical. In the data filling, the fish Pimephales promelas was selected because it is
commonly used in fish toxicity studies and there was sufficient analog data available to be used to fill
data gaps. The data gap filling was initiated by trend analysis, as it is the appropriate data gap-filling
method for quantitative endpoints such as LC50 from 96-hour acute toxicity study in fish. The results
were subsequently refined by endpoint specific profiler – Aquatic toxicity classification by ECOSAR,
Chemical elements, organic functional groups (US EPA), Acute aquatic toxicity MOA by OASIS. The
prediction was considered satisfactory because of the chemical and structural similarity with similar
mechanisms of toxicity between the target chemical and the analogs. - GLP compliance:
- not specified
- Analytical monitoring:
- not required
- Test type:
- other: QSAR
- Key result
- Dose descriptor:
- LC50
- Effect conc.:
- >= 0.65 - <= 111 mg/L
- Remarks on result:
- not measured/tested
- Sublethal observations / clinical signs:
Database(s) used:
- Aquatic OASIS
- ECHA CHEM
- ECOTOX
Category boundaries (applicability domain):
- Active descriptor(s) range:
- log Kow: from -0.69 to 4.16 target chemical is in domain
- Response range:
- LC50: from 3.02 to 5.55 log(1/mol/L) (from 0.65 to 111 mg/L)
Profilers:
- Esters (Acute toxicity) (US-EPA New Chemical Categories) (primary grouping)
target chemical is in domain
- Aquatic toxicity classification by ECOSAR (subcategorization)
target chemical is in domain
- Chemical elements (subcategorization)
target chemical is in domain
- Organic functional groups (US EPA) (subcategorization)
target chemical is in domain
- Acute aquatic toxicity MOA by OASIS (subcategorization)
target chemical is in domain
Additional data pruning:
Data inconsistency filter 10 value(s) from 8 chemical(s)
Cannot calculate X descriptor(s) 7 value(s) from 7 chemical(s)
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Response range:
LC50: from 3.02 to 5.55 log(1/mol/L) (from 0.65 to 111 mg/L)
Reference
Description of key information
The site will be operating by the end of 2020 and it will be closed in 2021. The last campaign of DAT production is planned in 2019.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.