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EC number: 600-026-8 | CAS number: 1000817-22-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 215 (Fish, Juvenile Growth Test)
- GLP compliance:
- yes
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 24B187
- Expiration date of the lot/batch: 23 march 2016
- Purity test date: 100%
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: cool place
- Stability under test conditions:stable in container after opening/ in water/in soil/in light - Analytical monitoring:
- yes
- Remarks:
- DOC analysis
- Details on sampling:
- The new solutions of 0.56, 1.4, 3.5, 8.9, 22 and 56 mg/L at 0, 6, 13, 20 and 27 days and the old solutions at 1, 7, 14, 21 and 28 days were sampled for DOC analysis.
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: 1.7, 4.2, 10.5, 20.7, 66 and 168 mg of the test substance for each test group were weighed into beakers and dissolved with test water to obtain the test substance suspensions. The suspensions were transferred into 5L jars and tghe beakers were washed with test water respectively. The test water was added up to 3000 mL to obtain the loading concentrations. The suspensions were stirred with magnetic stirrers for about 24h and filtered through 0.22 µm filter membranes. - Test organisms (species):
- other: Gobiocypris rarus
- Details on test organisms:
- TEST ORGANISM
- Common name: rare minnow
- Source: Southwest University
- Weight at study initiation (mean and range, SD): 50 - 100 mg
FEEDING DURING TEST
- Food type: Artemia (eggs obtained from Shandong besen Feed Co Ltd)
- Amount: 4% body weight per day in two 2% body weight portions per day - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 28 d
- Hardness:
- 150 mg/L as CaCO3
- Test temperature:
- 21.3 - 23.8 °C
- pH:
- 7.60 - 8.25
- Dissolved oxygen:
- 61 - 100% saturation
- Nominal and measured concentrations:
- Nominal: 0.56, 1.4, 3.5, 8.9, 22 and 56 mg/L loading rate WAFs
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 5 L glass jars containing 2 L test solution
- Renewal rate of test solution (frequency/flow rate): every 24h
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: dechlorinated tap water
- Total organic carbon: 1.9 mg/L
- Culture medium different from test medium: no
- Intervals of water quality measurement: The pH and dissolved oxygen of all test groups were measured at 0, 6, 13, 20, 27d (new solutions) and 1, 7, 14, 21 and 28d (old solutions). The temperature was continuously measured in an additional container with test water.
OTHER TEST CONDITIONS
- Photoperiod: 14h light/10h dark
- Light intensity: artificial light of white fluorescent lamp
EFFECT PARAMETERS MEASURED: the fish were examined daily during the test period and any abnormalities and mortalities were recorded. - Reference substance (positive control):
- no
- Key result
- Duration:
- 28 d
- Dose descriptor:
- NOELR
- Effect conc.:
- 1.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- growth rate
- Duration:
- 28 d
- Dose descriptor:
- LOELR
- Effect conc.:
- 3.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- growth rate
- Duration:
- 28 d
- Dose descriptor:
- EL50
- Effect conc.:
- 3.46 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- growth rate
- Duration:
- 28 d
- Dose descriptor:
- EL10
- Effect conc.:
- 0.55 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- growth rate
- Remarks on result:
- other: 0.227 - 1.96 mg/L CL
- Duration:
- 28 d
- Dose descriptor:
- other: LL100
- Effect conc.:
- 22 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- mortality
- Details on results:
- - Fish weights (individual and mean values) on day 0, 14 (if measured) and 28: see Table 1 (attached)
- Tank-average or pseudo-specific growth rates for periods 0-28d: see Table 2 (attached)
- Type of and number with morphological abnormalities: none
- Type of and number with behavioural abnormalities: The mortality rates in the treatments of 22 and 56 mg/L were 100%. The abnormal behavior in the 56 mg/L treatment were found at 19 - 24d and at 22 - 25d for the 22 mg/L treatment. The abnormal behavior was overturning and losing of balance. There were no abnormal behavior and mortality in any other treatment. - Validity criteria fulfilled:
- yes
Reference
DOC concentration of the test solutions:
The new solutions of 0.56, 1.4, 3.5, 8.9, 22 and 56 mg/L at 0, 6, 13, 20 and 27 days and the old solutions at 1, 7, 14, 21 and 28 days were detected. The actual DOC concentrations of the new test substance solution at the starting of the test and after renewal (after subtraction of the background value) were 4.61 - 18 mg/L. The old test substance solutions before renewal and at the end of the test were 4.78 - 17.7 mg/L (equivalent to 87.8 - 104% of the measured concentrations of the new solutions). The average DOC concentrations of the 0.56, 1.4, 3.5, 8.9, 22 and 56 mg/L treatments (after subtraction of the background value) were 7.81, 8.63, 8.44, 9.97, 13.2 and 16.5 mg/L, respectively. The fact that the actual DOC concentrations remained in the range of 80 - 120% of the measured concentration of the new solutions over the 24h exposure intervals indicate that the test concentrations were stable.
Description of key information
NOELr (28d) = 1.4 mg/L (nominal, loading rate) for Gobiocypris rarus (OECD 215)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1.4 mg/L
Additional information
One study investigating the long-term toxicity of Fatty acids, C8-18 and C18-unsatd., reaction products with diethanolamine and propylene oxide (CAS 1000817-22-0) to freshwater fish is available. The study was performed according to OECD guideline 215 under GLP conditions using Gobiocypris rarus as test organism (Liu 2016). Loading rate WAFs between 0.56 and 56 mg/L were tested under semi-static conditions. DOC analysis indicated stable test solutions. The 28d-NOELr value was determined to be 1.4 mg/L based on nominal loading concentrations.
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