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Diss Factsheets
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EC number: 224-427-9 | CAS number: 4355-11-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion
- Remarks:
- in vitro
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)
- Principles of method if other than guideline:
- Commercial name: CORROSITEX ®
Supplier: InVitro INTERNATIONAL - GLP compliance:
- yes
Test material
- Reference substance name:
- Cyclohexanediacetic acid
- EC Number:
- 224-427-9
- EC Name:
- Cyclohexanediacetic acid
- Cas Number:
- 4355-11-7
- Molecular formula:
- C10H16O4
- IUPAC Name:
- 2-[1-(carboxymethyl)cyclohexyl]acetic acid
- Details on test material:
- The membrane barrier (biobarrier) consists of two components: a proteinaceous macromolecular aqueous gel and a permeable supporting membrane. The proteinaceous gel should be impervious to liquids and solids but it could be corroded and made permeable.
The proteinaceous gel serves as the target for the test item and is placed on the surface of the supporting membrane and is allowed to gel, prior to placing the membrane barrier over the indicator solution.
The proteinaceous gel should be of equal thickness and density on the entire surface and with no air bubbles or defects that could affect its functional integrity.
The permeable supporting membrane provides mechanical support to the proteinaceous gel during the gelling process and exposure to the test item. The supporting membrane prevents sagging or shifting of the gel and is readily permeable to all test substances.
Constituent 1
Results and discussion
Any other information on results incl. tables
The results of main assay are showed in Table:
Test or control item |
Sample code |
Chemical/physical change |
Breakthrough observation time (min)
|
|
Value observed |
Mean ± SD
|
|||
CYCLOHEXANEDIACETIC ACID
|
1 |
No change |
65.00 |
N/A |
2 |
No change |
65.00 |
||
3 |
No change |
60.00 |
||
4 |
No change |
65.00 |
||
Valeroyl Chloride
|
+ |
Colour change: red |
11.97 |
N/A |
Citric Acid 10%
|
- |
No change |
60.00 |
N/A |
The test item did not show the ability to pass the membrane in the four replicates within the maximum observation time (65 minutes).
Positive and negative control results indicated a good functioning of the test system.
Positive control was corrosive at 11.97 minutes, in agreement with the RTC historical control value.
Negative control was not corrosive at 60 minutes.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- The test item is not defined as corrosive to the skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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