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EC number: 217-101-2 | CAS number: 1739-84-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
The oral LD50 was ca. 1300 mg/kg bw, the inhalation LC50 (after 4 h exposure) was > 3 mg/L and the dermal LD50 was > 200 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 330 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Meets generally accepted scientific standards, well documented and acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- prior to the adoption of OECD403 in 1981
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: SPF-Zucht, Firma MUS RATTUS, Brunnthal
- Weight at study initiation: 185 +/- 15 g
- Diet: Herilan MRH (Firma H. Eggersmann, Rinteln/Weser), ad libitum
- Water: ad libitum - Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Aerosol generation: generated using a continuous infusion pump to lead the water/substance mixture (50%) through a two-fluid nozzle with compressed air
-Tubes in which the snout extends into an inhalation chamber for exposure - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 3.01 mg/l (analytical), 19.59 mg/l (nominal)
2.39 mg/l (analytical), 15.33 mg/l (nominal) - No. of animals per sex per dose:
- 10
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs and body weight - Statistics:
- The statistical analysis of the experiment was based on the binomial test by the computational center at BASF.
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 3 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 12 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Remarks on result:
- other: conversion of the 4-h LC50 according to the Haber-rule
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 3 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 12 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Remarks on result:
- other: conversion of the 4-h LC50 according to the Haber-rule
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- 3 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- 12 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Remarks on result:
- other: conversion of the 4-h LC50 according to the Haber-rule
- Mortality:
- No mortality occured
- Clinical signs:
- other: Watery, reddish eyes and nasal secretions. Shock manner or rapid breathing. Long-legged, tumbling movement. Scruffy look. Matted fur. Alopecia. 2 out of 20 male animals showed nose burns. On the day of necropsy symptoms were still recorded.
- Body weight:
- Slight differences in body weight gain were observed in the test groups compared to the control group.
- Gross pathology:
- No treatment related findings.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating conc.
- Value:
- 300 mg/m³ air
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Meets generally accepted scientific standards, well documented and acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- prior to the adoption of OECD402 in 1981
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- Vienna White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: M.GAUKLER (6050 Offenbach, Germany)
- Weight at study initiation: 2.9 kg
- Diet: Ssniff K, standard diet for rabbits and guinea pigs (Firma INTERMAST GMBH, Soest), ad libitum
- Water: ad libitum - Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- TEST SITE
15 to 24 hrs before treatment, dorsal and lateral parts of the body of the animals were shaved with an electric clipper exposing an area of approximatly 50 cm2
- Type of wrap if used: aluminium foil fixed with adhesive tape
REMOVAL OF TEST SUBSTANCE
- Washing: with warm water or a water/Lutrol mixture
- Time after start of exposure: 24 hours
TEST MATERIAL
- Concentration: 50 % solution - Duration of exposure:
- 24 hours
- Doses:
- 200 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 8 days
- Frequency of observations and weighing: after 1, 24 and 48 hours and on day 8
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs and local skin irritaion - Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None of the animals died during the observation period.
- Clinical signs:
- other: No abnormal observations were reported.
- Gross pathology:
- No abnormal observations were reported.
- Other findings:
- 24 hours after application the animals show a mild primary skin irritation which remained consistent for almost 48 hours.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 200 mg/kg bw
Additional information
Oral toxicity
In an oral toxicity study, comparable to OECD guideline 401, US-rats (5/sex/dose) were administered 1,2-dimethylimidazole at 200, 800, 1000, 1250 and 1600 mg/kg bw by single dose (gavage) followed by a 7-day observation period (1965, RL2). Clinical signs included partly/slight staggering, shaking, slight dyspnoea, mild cramps, trembling, apathy, rough coat, bloody crusted nose and eyes. Findings at necropsy showed stomach filled with test substance and bleeding of gastric mucosa. The LD50 was ca 1300 mg/kg bw.
Inhalation toxicity
In an inhalation toxicity study, comparable to OECD 403, Sprague-Dawley rats (10/sex/dose) were exposed (nose/head only) for 4 hours to 3.01 and 2.39 mg/L 1,2 -dimethylimidazole followed by a 14 day observation period (1979, RL2). No mortality occurred. Clinical signs included watery, reddish eyes and nasal secretions. Shock manner or rapid breathing. Long-legged, tumbling movement. Scruffy look. Matted fur. Alopecia. 2 out of 20 male animals showed nose burns. On the day of necropsy symptoms were still recorded. No abnormal findings at necropsy were observed. The LC50 was > 3 mg/L.
In another study, comparable to OECD 403, in which rats (3/sex-dose) were exposed for 8 hours to a saturated 1,2-dimethylimidazole atmosphere vapour at 20°C (0.9 mg/L) no deaths were observed during a 14-day observation period (1965, RL2). The LC50 was > 0.9 mg/L.
Dermal toxicity:
In an acute dermal toxicity study, similarly performed according to OECD guideline 402, Vienna white Rabbits (5/sex) were administered 1,2 -dimethylimidazole (200 mg/kg bw) (1979, RL2). 1,2-Dimethylimidazole was dissolved in distilled water and applied on the skin (skin area of approx 50 cm2) and covered in aluminium foil fixed with adhesive tape. The treated skin was washed after 24 hours and a 8 day observation period followed. No mortality was observed during this period resulting in a LD50 > 200 mg/kg bw.
Justification for classification or non-classification
As no mortality was observed in the acute inhalation toxicity study (LC50 > 3.01 mg/l) and acute dermal study (LD50 > 200 mg/kg bw), classification for acute inhalation and dermal toxicity is not needed.
Based on the available data, 1,2 -dimethylimidazole has to be classified for acute oral toxicity. According to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008, the classification is H302, Cat. 4, which is in accordance with Annex VI.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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