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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-176-9 | CAS number: 104-12-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: results sufficiently stated
Data source
Reference
- Reference Type:
- publication
- Title:
- Maximum permissible concentration of p-chlorophenyl isocyanate in factory air
- Author:
- Frolova IN
- Year:
- 1 966
- Bibliographic source:
- Hygiene & Sanitation 31 (7-9), 481-483 (Engl. translation)
Materials and methods
- Study type:
- study with volunteers
- Endpoint addressed:
- eye irritation
- Principles of method if other than guideline:
- threshold of irritating effects on eyes (no further data) was determined
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-chlorophenyl isocyanate
- EC Number:
- 203-176-9
- EC Name:
- 4-chlorophenyl isocyanate
- Cas Number:
- 104-12-1
- Molecular formula:
- C7H4ClNO
- IUPAC Name:
- 1-chloro-4-isocyanatobenzene
- Details on test material:
- TS-Freetext:
4-Chlorophenyl isocyanate, no purity specified
Constituent 1
Method
- Subjects:
- human volunteers (no further data)
- Route of exposure:
- ocular
- Reason of exposure:
- intentional
- Exposure assessment:
- not specified
Results and discussion
- Clinical signs:
- subjects complained of unpleasant sensations in their eyes
Any other information on results incl. tables
RM-Freetext:
In the case of human subjects the threshold of irritating
action was 0.0008 mg/l for a one-minute exposure (no further
information from the English translation of the Russian
publication)
Applicant's summary and conclusion
- Executive summary:
In the case of human subjects the threshold of irritating action was 0.0008 mg/l for a one-minute exposure.
The subjects complained of unpleasant sensations in their eyes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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