Registration Dossier
Registration Dossier
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EC number: 250-439-9 | CAS number: 31027-31-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: cited in BG 249 (Hoechst study)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- p-isopropylphenyl isocyanate
- EC Number:
- 250-439-9
- EC Name:
- p-isopropylphenyl isocyanate
- Cas Number:
- 31027-31-3
- Molecular formula:
- C10H11NO
- IUPAC Name:
- 1-isocyanato-4-(propan-2-yl)benzene
- Details on test material:
- no data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- see observation period
- Observation period (in vivo):
- 14 d
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- ca. 4
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 d
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- ca. 1
- Max. score:
- 2
- Reversibility:
- fully reversible within: 7 d
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- ca. 2
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 d
- Irritant / corrosive response data:
- Within 72 h after application of substance complete corneal opacity occured. Conjunctiva were severe and iris moderately inflamed. 2 of the 3 treated animals died on day 4 or 8 after application of substance. At the surviving animal signs of inflammation and corneal opacity were reversible on day 7and 14 respectively.
- Other effects:
- 2 out of 3 animals died during post observation period
Any other information on results incl. tables
Within 72 after application of the test substance, a complete corneal opacity, pronounced inflammation of conjuctivae and slight inflammation of the iris was seen. Two out of 3 animals died on day 4 or day 8 after the application of the test substance. On the animal which survived, the inflammation and opacity was reversibel on day 7 and 14, respectively.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information
- Executive summary:
method: eye irritation study according OECD 405
result: substance was classified as irritating
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