Registration Dossier
Registration Dossier
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EC number: 204-398-9 | CAS number: 120-46-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,3-diphenylpropane-1,3-dione
- EC Number:
- 204-398-9
- EC Name:
- 1,3-diphenylpropane-1,3-dione
- Cas Number:
- 120-46-7
- Molecular formula:
- C15H12O2
- IUPAC Name:
- 1,3-diphenylpropane-1,3-dione
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- 0.1g
- Observation period (in vivo):
- 1, 24, 48, 72 hours
- Number of animals or in vitro replicates:
- 3 male animals
Results and discussion
In vivo
Results
- Remarks on result:
- other: please see "any other information on results incl. tables"
- Remarks:
- please see "any other information on results incl. tables"
Any other information on results incl. tables
OCULAR REACTION OBSERVED TREATED EYE
|
Cornea: No abnormality was observed during the confirmatiory test
Iris: No abnormality was observed during the confirmatiory test
Conjunctivae (Congestion): Some blood vessels definitely hyperaemic were observed in the treated eye of the rabbit n. 367. No abnormality was observed in the treated eye of the rabbit N.368 during the confirmatory test.
Conjunctivae (Chemosis): Any swelling above normal was observed/
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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