Registration Dossier
Registration Dossier
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EC number: 235-747-3 | CAS number: 12650-88-3
Endpoint summary
Administrative data
Description of key information
Additional information
No specific information exists on the toxicity of Lysozyme to aquatic life of lysozyme, however considering that Lysozyme is naturally occurring in many organisms, including aquatic organisms, it is expected to be non-toxic for aquatic life.
Acute toxicity has been investigated on the base of the comparison with other enzymes and data available on the three trophic levels, i.e. algae, invertebrates and fish.
The analyses have not revealed significant toxic effects, nor reasons of concern. Data evaluated as reliable are consistent and characterize the enzymes as non-toxic to aquatic life.
Since available data are not specific for Lysozyme, it is preferred to make a qualitative assessment.
In the chronic exposure context, it has to be considered that enzymes are proteins, hydrophilic and readily biodegradable; in nature, they are involved at any level of the food chain and in the microbial biodegradation. All enzyme classes are readily biodegradable and degradation products are primarily peptides and amino acids, followed by carbon dioxide and water which cause no harm to nature.
On the basis of the rapid elimination from the eco-systems, long-term testing can be considered less relevant.
Moreover the bioconcentration can generally be neglected, due to the hydrophilic properties and ready biodegradability of proteins. Additionally, Lysozyme is naturally present in the environment and in case releases would occur they would be minimal in relation to natural background concentrations.
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