Registration Dossier
Registration Dossier
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EC number: 909-122-7 | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study report which meets basic scientific principles
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
- Reference Type:
- secondary source
- Title:
- Fragrance raw material monographs
- Author:
- Ford RA
- Year:
- 1 988
- Bibliographic source:
- Food and Chemicals Toxicology, 26(4), 413
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- part of dermal acute toxicity study (7.2.3 Moreno1977.Acute toxicity: dermal rabbit)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3,6,10-trimethylundeca-3,5,9-trien-2-one
- EC Number:
- 214-245-8
- EC Name:
- 3,6,10-trimethylundeca-3,5,9-trien-2-one
- Cas Number:
- 1117-41-5
- Molecular formula:
- C14H22O
- IUPAC Name:
- 3,6,10-trimethylundeca-3,5,9-trien-2-one
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Doses: 2500, 5000 mg/kg bw - Duration of treatment / exposure:
- 24 h
- Observation period:
- at least 9 days
- Number of animals:
- 2500 mg/kg bw: 4
5000 mg/kg bw: 10
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: days 1-9
- Score:
- > 1
- Reversibility:
- not fully reversible within: 9 days
- Irritant / corrosive response data:
- 2500 mg/kg bw:
- moderate redness in 2/4 rabbits
- severe redness in 2/4 rabbits
- severe edema in all 4 rabbits
- skin thick and hard in all 4 rabbits at necropsy
5000 mg/kg bw:
- severe redness in 10/10 rabbits
- moderate edema in 9/10 rabbits
- severe edema in 1/10 rabbits
- skin red and edematous in 6/10 rabbits
- skin thick and hard in 4/10 rabbits at necropsy
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- irritating, as severe reactions are observed and effects were prominent at least 9 days after application
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