Trichloro(2,4,4-trimethylpentyl)silane

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Study conducted in accordance with a national standard method and with GLP.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1995

Report date:

1995

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Trichloro(2,4,4-trimethylpentyl)silane

EC Number:

242-262-0

EC Name:

Trichloro(2,4,4-trimethylpentyl)silane

Cas Number:

18379-25-4

Molecular formula:

C8H17Cl3Si

IUPAC Name:

trichloro(2,4,4-trimethylpentyl)silane

Test animals

Species:

rabbit

Strain:

New Zealand White

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Myrtle’s Rabbitry, Thompson Station, TN, USA
- Age at study initiation: not stated
- Weight at study initiation: 2.25 kg
- Housing: 1/suspended stainless steel cage
- Diet: standard diet ad libitum
- Water: drinking water ad libitum
- Acclimation period: at least 5 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 70 deg F
- Humidity (%): 43
- Air changes (per hr): 12
- Photoperiod (hrs dark / hrs light): 12 h/ 12 h

IN-LIFE DATES: From: 21 Nov 1994 To: 21 Nov 1994 (single day)

Test system

Type of coverage:

semiocclusive

Preparation of test site:

shaved

Vehicle:

unchanged (no vehicle)

Controls:

no

Amount / concentration applied:

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
- Concentration (if solution): neat

Duration of treatment / exposure:

3 minutes.
[Subsequent 1-h and 4-h exposures were abandoned when the test material was determined to be corrosive.]

Observation period:

3 minutes

Number of animals:

1
[5 additional animals planned for longer exposure durations were not used.]

Details on study design:

TEST SITE
- Area of exposure: 2.5 cm x 2.5 cm
- % coverage: not stated
- Type of wrap if used: gauze and semipermiable elastic wrap

REMOVAL OF TEST SUBSTANCE
- Washing (if done): wiped with dry then moist gauze
- Time after start of exposure: 3 minutes

SCORING SYSTEM: Draize (1959)

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Basis:

animal #1

Time point:

other: 3 mins

Score:

4

Max. score:

4

Reversibility:

other: not examined

Remarks on result:

other: severe blanching

Results 2

Irritation parameter:

edema score

Basis:

animal #1

Time point:

other: 3 mins

Score:

3

Max. score:

4

Reversibility:

other: not examined

Irritant / corrosive response data:

Exposure for 3 minutes was associated with severe erythema, moderate oedema and sever blanching (covering more than 50% of the test site). No further exposures were undertaken and the test animal was humanely euthanized. (See also table1.)

Other effects:

None reported

Any other information on results incl. tables

Table 1: Irritant/corrosive response data

Score at time point / Reversibility	Erythema	Edema	Blanching
	Max. score: 4	Max. score: 4	Max. score: 4
3 min	4	3	4

 

 

Applicant's summary and conclusion

Interpretation of results:

corrosive

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

A reliable study conducted in a similar manner to OECD 404 and with GLP status, found a 3-minute contact with the test material to be corrosive to the skin of rabbits.