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EC number: 291-793-4 | CAS number: 90480-58-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012-03-23 to 2012-05-25
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- Two vessels were set up in a parallel design at 20 ± 1.0 °C, each solution was sampled several times over time instead of setting up multiple vessels and sampling solutions from a different vessel at each sampling date.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2008
- Deviations:
- yes
- Remarks:
- Two vessels were set up in a parallel design at 20 ± 1.0 °C, each solution was sampled several times over time instead of setting up multiple vessels and sampling solutions from a different vessel at each sampling date.
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- signed 2011-02-07
- Type of method:
- flask method
- Water solubility:
- 320.6 other: mg/L dissolved octanoic acid, zinc salt basic
- Temp.:
- 20 °C
- pH:
- >= 6 - <= 6.8
- Remarks on result:
- other: Estimated water solubility value calculated based on dissolved zinc and the zinc content of 22.6 %
- Water solubility:
- 72.47 other: mg/L dissolved Zn
- Temp.:
- 20 °C
- pH:
- >= 6 - <= 6.8
- Details on results:
- Under the conditions of this test (flask method; loadings of 2.0001 and 2.0000 mg/L in vessel A and B, respectively), a solubility equilibrium was reached during the 13 days of testing. The mean amount of dissolved Zn from day 2 until day 13 at 20.0 ± 1.0°C is 72.47 ± 3.32 mg/L (determined as dissolved Zn, separated by filtration from undissolved test item). This corresponds to a water solubility of dissolved octanoic acid, zinc salt basic of 320.6 ± 14.7 mg/L, calculated based on a zinc content of 22.6%. The pH measured in both test vessels remained relatively constant ranging from 6.0 – 6.6, except after 12 days in vessel B (pH of 6.8). In both method blanks the pH ranged from 5.9 to 6.6.
- Conclusions:
- Under the conditions of this test (flask method; loadings of 2.0001 and 2.0000 mg/L in vessel A and B, respectively), a solubility equilibrium was reached during the 13 days of testing. The mean amount of dissolved Zn from day 2 until day 13 at 20.0 ± 1.0°C is 72.47 ± 3.32 mg/L (determined as dissolved Zn, separated by filtration from undissolved test item). This corresponds to a water solubility of dissolved octanoic acid, zinc salt basic of 320.6 ± 14.7 mg/L, calculated based on a zinc content of 22.6%. The pH measured in both test vessels remained relatively constant ranging from 6.0 – 6.6, except after 12 days in vessel B (pH of 6.8). In both method blanks the pH ranged from 5.9 to 6.6.
Reference
Observations
During the study, undissolved test material was observed in the medium, especially on the surface. Furthermore, test material was adsorbed to the flask wall. After filtration, the solution was clear. In order to verify this, turbidity was measured in filtered samples (see Table 3 and Table 4). The turbidity of blank and test solutions appears to be similar (see below).
Temperature
The study was performed in a thermostatically controlled temperature precise incubation cabinet (Binder, Tuttlingen, Germany). Besides the constant display of 20.0 °C, the temperature inside the cabinet was measured by a reference thermometer and remained at 20.0 °C (reading accuracy of 0.3 °C) at every sampling point.
Solution pH
The pH measured in both test vessels remained relatively constant from 6.0 – 6.6, except after 12 days in vessel B (pH of 6.8). In both method blanks, the pH ranged from 5.9 to 6.6.The temperature measurements of the pH meter varied marginally from those of the reference thermometer and were not always at 20.0 ± 1.0 °C. The pH meter was calibrated for pH measurements every working week and furthermore verified every working day; however, this calibration was not performed for the temperature measurement since a reference thermometer was used during the test. All measured pH values are listed in Table 1and Table 2.
Table 1: Solution pH of solutions containing the test item
test day [d] |
sample |
temperature of pH measurement [°C] |
pH |
sample |
temperature of pH measurement [°C] |
pH |
2 |
A |
22.2 |
6.3 |
B |
22.1 |
6.4 |
3 |
A |
20.7 |
6.5 |
B |
21.5 |
6.5 |
4 |
A |
21.0 |
6.4 |
B |
21.8 |
6.5 |
12 |
A |
20.6 |
6.6 |
B |
21.5 |
6.8 |
13 |
A |
20.9 |
6.4 |
B |
21.7 |
6.6 |
Table 2: Solution pH of method blanks
test day [d] |
blank vessel |
temperature of pH measurement [°C] |
pH |
blank vessel |
temperature of pH measurement [°C] |
pH |
2 |
1 |
22.1 |
6.3 |
2 |
21.8 |
6.3 |
3 |
1 |
21.1 |
6.2 |
2 |
20.3 |
6.1 |
4 |
1 |
20.5 |
5.9 |
2 |
20.7 |
5.9 |
12 |
1 |
20.0 |
6.6 |
2 |
20.4 |
5.9 |
13 |
1 |
20.5 |
6.3 |
2 |
20.8 |
6.4 |
Turbidity
The turbidity was measured after filtering to verify that only dissolved zinc concentrations would get measured. The turbidity was always <<1 NTU, indicating that there was not any undissolved material left and that micelles did not form after the filtration step. Turbidity data are compiled in Table 3 and Table 4
Table 3: Turbidity of samples
test day [d] |
turbidity of sample vessel A [NTU] | turbidity of sample vessel B [NTU] |
2 |
0.05 |
0.09 |
3 |
0.10 |
0.08 |
4 |
0.04 |
0.11 |
12 |
0.06 |
0.02 |
13 |
0.10 |
0.04 |
Table 4: Turbidity of blanks
test day [d] |
turbidity of blank vessel 1 [NTU] |
turbidity of blank vessel 2 [NTU] |
2 |
0.09 |
0.06 |
3 |
0.03 |
0.05 |
4 |
0.03 |
0.04 |
12 |
0.02 |
0.03 |
13 |
0.04 |
0.06 |
Dissolved zinc concentrations
Dissolved zinc concentrations in all method blanks sampled at each time point were below the limits of detection (LOQs ranging from25 to 37) of the respective measurement series. All test samples were diluted (dilution factor 100), so that the respective zinc concentrations would be in the calibrated range of the ICP-OES instrument. The variation of zinc concentrations between subsequent sampling points is listed in Table 5 (in percent). Constant zinc concentrations as defined by the study guideline OECD 105 and the Regulation 440/2008/EC A.6 were measured during the 13 days of testing.
Table 5: Measured Zn concentrations in test samples (internal calculations were performed with more digits, values were rounded)
test day |
Zn conc. of samples |
mean Zn |
Zn conc. of samples |
mean Zn |
mean Zn |
variation between samplings |
2 |
73.09 |
73.36 ± 0.38 |
71.14 |
71.47 ± 0.46 |
72.41 + 1.15 |
- |
73.63 |
71.79 |
|||||
3 |
77.86 |
77.11 ± 1.06 |
75.07 |
75.75 ± 0.95 |
76.43 + 1.14 |
5.5 |
76.36 |
76.42 |
|||||
4 |
74.97 |
75.35 ± 0.54 |
75.46 |
75.05 ± 0.58 |
75.20 + 0.49 |
-1.6 |
75.73 |
74.64 |
|||||
12 |
69.32 |
67.46 ± 2.64 |
70.40 |
69.87 ± 0.76 |
68.66 + 2.11 |
-8.7 |
65.59 |
69.33 |
|||||
13 |
67.81 |
68.92 ± 1.57 |
70.70 |
70.34 ± 0.52 |
69.63 + 1.26 |
1.4 |
70.03 |
69.97 |
Table 6: Measured zinc concentrations in method blanks
test day |
Zn conc. blank A [µg/L] |
Zn conc. blank B [µg/L] |
LOD [µg/L] |
LOQ [µg/L] |
2 |
< LOD |
< LOD |
27 |
91 |
< LOD |
< LOD |
|||
3 |
< LOD |
< LOD |
27 |
91 |
< LOD |
< LOD |
|||
4 |
< LOD |
< LOD |
25 |
82 |
< LOD |
< LOD |
|||
12 |
< LOD |
< LOD |
37 |
125 |
< LOD |
< LOD |
|||
13 |
< LOD |
< LOD |
37 |
125 |
< LOD |
< LOD |
Description of key information
Based on measured maximum zinc concentrations, the water solubility of Octanoic acid, zinc salt basic is 320.6 mg/L at pH 6 and at 20 °C.
Key value for chemical safety assessment
- Water solubility:
- 320.6 mg/L
- at the temperature of:
- 20 °C
Additional information
Under the conditions of this test (flask method; loadings of 2.0001 and 2.0000 mg/L in vessel A and B, respectively), a solubility equilibrium was reached during the 13 days of testing. The mean amount of dissolved Zn from day 2 until day 13 at 20.0 ± 1.0 °C is 72.47 ± 3.32 mg/L (determined as dissolved Zn, separated by filtration from undissolved test item). This corresponds to a water solubility of dissolved octanoic acid, zinc salt basic of 320.6 ± 14.7 mg/L, calculated based on a zinc content of 22.6 %. The pH measured in both test vessels remained relatively constant ranging from 6.0 – 6.6, except after 12 days in vessel B (pH of 6.8). In both method blanks the pH ranged from 5.9 to 6.6.
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