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Diss Factsheets
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EC number: 253-506-0 | CAS number: 37439-34-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1985
Materials and methods
- Principles of method if other than guideline:
- The test material was fed in the diet to male and female rats at targeted dose levels. Parameters evaluated were general health, food consumption, body weights and gains, haematology, serum chemistry, pre-study, mid-study and final urinanalysis, absolute and relative organ weights, gross lesions and histopathologic alterations.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- sodium 3,5,6-trichloro-2-pyridinol
- IUPAC Name:
- sodium 3,5,6-trichloro-2-pyridinol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 3-months
- Frequency of treatment:
- No data
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
0 (control) mg/kgBW/day
Basis:
other: targeted dose
- Remarks:
- Doses / Concentrations:
10 mg/kgBW/day
Basis:
other: targeted dose
- Remarks:
- Doses / Concentrations:
30 mg/kgBW/day
Basis:
other: targeted dose
- Remarks:
- Doses / Concentrations:
100 mg/kgBW/day
Basis:
other: targeted dose
- No. of animals per sex per dose:
- No data
- Control animals:
- yes
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 30 mg/kg bw/day (nominal)
- Based on:
- not specified
- Sex:
- male/female
- Basis for effect level:
- other: see 'Remark'
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Increased liver and kidney weights were observed in both males and females at the highest dose level.
During study, administration of the test material was also associated with observations of staining and matting of the perineal hair, often in females of the highest dose level, less often in females of the middle dose, occasionally on males of the highest dose group; and frequently in females of the low dose level group. The cause of this perineal soiling and its toxicological significance is uncertain.
Body weights and weight gains of the male middle dose level group increased along with increased food consumption, perhaps because of increased palatability.
No adverse gross or histopathological findings, urinalysis, serum chemistry, or haematology changes were found that corresponded with the increased relative liver and kidney weights, the perineal staining and matting, or the increased food consumption, body weights and body weight gains.
Applicant's summary and conclusion
- Conclusions:
- The NOAEL for males and females was 30 mg/kgBW/day.
- Executive summary:
Increased liver and kidney weights were observed in both males and females at the highest dose level.
During study, administration of the test material was also associated with observations of staining and matting of the perineal hair, often in females of the highest dose level, less often in females of the middle dose, occasionally on males of the highest dose group; and frequently in females of the low dose level group. The cause of this perineal soiling and its toxicological significance is uncertain.
Body weights and weight gains of the male middle dose level group increased along with increased food consumption, perhaps because of increased palatability.
No adverse gross or histopathological findings, urinalysis, serum chemistry, or haematology changes were found that corresponded with the increased relative liver and kidney weights, the perineal staining and matting, or the increased food consumption, body weights and body weight gains.
The NOAEL for males and females was 30 mg/kgBW/day.
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