Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-257-6 | CAS number: 93-55-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The substance is expected to possess a low potential for bioaccumulation (log Kow ≤ 3).
Additional information
There are no experimental available data on the bioaccumulation potential of propiophenone, however this property can be screened, on the basis of the partition coefficient octanol-water.
As mentioned in the specific endpoint (Iuclid section 4.7) the log Pow of propiophenone has been investigated uding fast-gradient HPLC method, which was developed to estimate the lipophilicity of substances. Propiophenone was used as a reference compound and its retention time was used to estimated the logPow of other substances. An excellent correlation was found between the results of the experimental determined and the literature log P values. The log Pow of the substance resulted to be 2.71 (Zheng.and West, 2009), thus the substance is expected to possess a low potential for bioaccumulation (log Kow ≤ 3).
The bioaccumulation potential has also been estimated using BCFBAF v3.01*, for completeness sake. The results confirm the expectation of a low potential for bioaccumulation.
Log BCF from regression-based method resulted to be 0.527 (BCF: 3.364 l/kg wet-wt). The log Biotransformation Half-life (HL) has been estimated to be -0.8179 days (HL: 0.1521 days). Log BCF and log BAF Arnot-Gobas method (upper trophic) have been estimated to be 1.099, in both cases (BCF and BAF: 12.57). The estimation tool BACFBAF v.3.01 based the calculation on a log Kow of 2.19 (experimental value authomatically recognized by the tool).
The estimated values does not significantly change if the experimental determined logPow of 2.71 is entered for the calculation: log BCF from regression-based method resulted 0.870 and log Biotransformation Half-life -0.6581 days. Based on Arnot-Gobas method (upper trophic) both log BCF and log BAF values have been estimated to be 1.521.
*BCFBAF v. 3.01 is an application contained in the EpiSuite 4.1, the suite of physical/chemical property and environmental fate estimation programs developed by the EPA’s Office of Pollution Prevention Toxics and Syracuse Research Corporation (SRC).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.