Registration Dossier
Registration Dossier
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EC number: 260-375-3 | CAS number: 56773-42-3
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary literature
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
- Principles of method if other than guideline:
- The objective of this study was to determine the percutaneous absorption potential of FC-128 in male and female albino rabbits
- GLP compliance:
- no
Test material
- Reference substance name:
- Potassium N-ethyl-N-[(heptadecafluorooctyl)sulphonyl]glycinate
- EC Number:
- 221-062-7
- EC Name:
- Potassium N-ethyl-N-[(heptadecafluorooctyl)sulphonyl]glycinate
- Cas Number:
- 2991-51-7
- IUPAC Name:
- potassium {ethyl[(heptadecafluorooctyl)sulfonyl]amino}acetate
- Details on test material:
- Fluorad FC-128 = Potassium N-ethyl-N- [(heptadecafluorooctyl)sulfonyl] glycinate CAS No. 2991-51-7
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
Results and discussion
Any other information on results incl. tables
No mortalities or untoward behavorial reactions were noted during the 28 day study. Body weight losses were noted in three females at the end of the study. Necropsies were performed on all animals upon termination of the study with no visible lesions noted.
Preliminary serum analysis indicates dermal absorption of FC-128 in albino rabbits, however, due to the limited number of samples
analyzed by the sponsor, no concrete conclusion may be drawn.
Applicant's summary and conclusion
- Executive summary:
The test article was administered by dermal application to ten male and ten female rabbits a dosage level of 2,000 mg/kg body weight
for a 24 hour exposure period. No mortalities or untoward behavorial reactions were noted during the 28 day study. Body weight losses were noted in three females at the end of the study. Necropsies were performed on all animals upon termination of the study with no visible lesions noted.
Preliminary serum analysis indicates dermal absorption of FC-128 in albino rabbits, however, due to the limited number of samples
analyzed by the sponsor, no concrete conclusion may be drawn.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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