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EC number: 228-567-1 | CAS number: 6297-03-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
repeated dose toxicity (rat, 90 day study): NOAEL > 1000 mg/kg bw
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Additional information
The oral toxicity of the test substance dioctylether was tested by daily administration to rats, has been investigated over a period of 13 consecutive weeks.Three groups, each of 10 male and 10 female rats (strain Crl:CD), received the test substance daily by oral gavage (5 ml) at dosages of 100, 300, and 1000 mg/kg/day for a minimum of 13 consecutive weeks. A fourth similarly constituted group received the vehicle alone (sun flower oil) and acted as a control.No death occurred during the study. Daily post‑dose observations did not show any significant signs. Detailed clinical signs with neurotoxicity assessment did not show any treatment‑related effects. Neurotoxicity tests and measurements performed at the end of the treatment did not show changes attributable to the test substance.With regard to body weight, no statistically significant differences were observed between control and treated groups. No test item-related influence was observed in food consumption. No findings were seen in the ophthalmic examination performed at the end of the study. No treatment‑related changes were observed in haematological parameters. No treatment‑related changes were seen in clinical chemistry parameters. No treatment-related pathological and histopathological changes were seen.No changes were seen in urinalysis. Treatment with 1000 mg/kg bw caused an increase in the absolute and related liver and kidney weights by up to 280 %. The increase is considered to be a non-specific adaptive change to the high work load of the liver caused by a dose level of 1000 mg/kg bw.Under the present test conditions, the no-observed-adverse-effect-level (NOAEL) for the test article was above 1000 mg/kg bw for systemic changes.
Dioctylether is used as a read-across substance for distearylether. The only difference is the longer alkyl chain. Dioctylether is regarded as a worst case in this respect because of the higher bioavailability due to the lower molecular weight. Furthermore, the possible metabolite stearyl alcohol is also not toxic after repeated oral exposure. It is unlikely that the ether of stearyl alcohol which might be build in the human body could have adverse systemic effects after repeated oral exposure.
Based on the reliability and relevance, this study has been used as key study.
Justification for classification or non-classification
Based on results of the key study the substance does not need to be classified according to GHS (Regulation (EU) 1272/2008) and also does not need to be classified according to DPD (67/548/EEC).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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