Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-046-9 | CAS number: 91-17-8
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Study poorly documented, small group sizes, study not up to current scientific standards, no data on dose level
Data source
Reference
- Reference Type:
- publication
- Title:
- Studio sperimentale sulla tossicità della tetralina e della decalina
- Author:
- Cardani A
- Year:
- 1 942
- Bibliographic source:
- Medicina del lavoro 33, 145-159; 169-184
Materials and methods
- Principles of method if other than guideline:
- Subacute dermal toxicity
- GLP compliance:
- no
Test material
- Reference substance name:
- Decahydronaphthalene
- EC Number:
- 202-046-9
- EC Name:
- Decahydronaphthalene
- Cas Number:
- 91-17-8
- Molecular formula:
- C10H18
- IUPAC Name:
- decahydronaphthalene
- Reference substance name:
- Dekalin
- IUPAC Name:
- Dekalin
- Details on test material:
- decahydronaphthalene, undiluted. No data on purity or isomer ratio
Constituent 1
Constituent 2
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Details on exposure:
- Route of Administration: dermal
- Duration of treatment / exposure:
- 14 days
- Frequency of treatment:
- 2 hours/day
Doses / concentrations
- Remarks:
- Doses / Concentrations:
undiluted application to 6 cm2 of clipped skin; volume not given
Basis:
- No. of animals per sex per dose:
- 1
- Control animals:
- no
- Details on study design:
- Post-exposure period: none
One animal died after 10 days, the other after 14 days. Both exhibited necrosis at the treatment sites, and liver and kidney changes.
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
