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Physical & Chemical properties

Water solubility

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Description of key information

The water solubility of test substance was determined at 1900 mg/L.

Key value for chemical safety assessment

Water solubility:
1 900 mg/L
at the temperature of:
20 °C

Additional information

The water solubility of the test substance was determined in a study according to OECD TG 105 (shake flask method) and in compliance with GLP criteria (NOTOX BV, 2010). In this study, three aliquots of the test substance were prepared at nominal concentrations of approximately 5000 mg/L (no headspace). The three vessels were then stirred for either 1, 3 or 5 hours. In each water sample after the stirring periods an excess of the liquid test substance was observed at the bottom of the vial. Centrifugation or filtration to remove the excess of the test substance was not required since the excess of the test substance was phase separated from the water at the bottom of the vial. Subsamples of the clear aqueous phases were 1000 times diluted to obtain an end solution of water containing 1% (v/v) acetonitrile and concentrations within the prepared calibration range. The pH of each of the water mixtures was determined. As the blank, the same volume of double distilled water was stirred for 5 hours. The blank solution was pretreated identically as the water samples from the flask method. From the three tests water solubilities of 1860 mg/L, 1940 mg/L and 1890 mg/L were reported after respective stirring times of 1, 3 and 5 hours. The maximum difference (MD) of the concentrations determined in the 1, 3 and 5 hour test samples was