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EC number: 271-843-1 | CAS number: 68609-93-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From December 03, 1985 to December 17, 1985
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 9-Octadecenoic acid (Z)-, sulfonated, potassium salts
- EC Number:
- 271-843-1
- EC Name:
- 9-Octadecenoic acid (Z)-, sulfonated, potassium salts
- Cas Number:
- 68609-93-8
- Molecular formula:
- A generic formula cannot be provided for this UVCB substance. The alkyl chain length of the sulfonated fatty acids range from C12-C22, however the major alkyl chain is C18.
- IUPAC Name:
- 9-Octadecenoic acid (Z)-, sulfonated, potassium salts
- Test material form:
- other: liquid
- Details on test material:
- -- Name of test material (as cited in study report) and in the signed statement on substance identity provided by the data holder: Lankropol OPA
- Physical state: Dark amber liquid containing 55% oleic acid, sulfonated, potassium salts and 45% water
- Received: November 15 1985
-- Storage: Ambient temperature
- Stability and absorption: Not determined
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Sprague-Dawley derived strain
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charres River U.K. Limited, Margate, Kent, England
- Age at study initiation: Four to six weeks
- Weight at study initiation: 105 to 140 g
- Fasting period: Access to food only was prevented overnight prior to and approximately 4 h after dosing
- Housing: Metal cages with wire mesh floors
- Diet: Standard laboratory rodent diet (i.e., Labsure LAD 1) ad libitum
- Water: ad libitum
- Acclimation period: minimum period of 6 d
- Identification: Each animal was identified by cage number and ear punching
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21°C and 22°C minimum and maximum temperatures respectively
- Humidity (%): 63%
- Air changes (per hr): 15 air changes/h
- Photoperiod (hrs dark / hrs light): 12 h light/dark cycle
IN-LIFE DATES: From: To:
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 4.4 mL/kg
5.0 g/kg bw based on a specific gravity of 1.125 - Doses:
- 5.0 g/kg bw, equivalent to 2,723 mg/kg bw active ingredient
- No. of animals per sex per dose:
- Five/sex/dose (main study)
Two/sex/dose (preliminary study) - Control animals:
- not specified
- Details on study design:
- Preliminary study
A trial test was carried out by dosing two male and two female rats at 2,723 mg/kg bw active ingredient.
Main study
A group of ten rats (i.e., five males and five females) was treated at 5.0 g/kg bw
Treatment procedure
The appropriate dose volume of the test substance was administered to each rat using a syringe and plastic catheter.
Observation period
5 and 14 d for preliminary and main studies respectively
Observation
Animals were observed soon after dosing; then at frequent intervals for the remainder of Day 1. On subsequent days the animals were observed at least twice per day. Clinical signs were recorded at each observation.
The following were recorded on the main study:
-The nature, severity, approximate time of onset and duration of each toxic sign.
-Individual bodyweights of rats on Days 1 (day of dosing), 8 and 15.
-All animals on the main study were killed on Day 15 by cervical dislocation and were subjected to a macroscopic post mortem examination which consisted of opening the abdominal and thoracic cavities. The macroscopic appearance of abnormal organs when present was recorded
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 723 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- No deaths occurred during the whole study
- Clinical signs:
- other: Signs of reaction to treatment observed shortly after dosing in all rats were pilo-erection, abnormal body carriage (i.e., hunched posture), abnormal gait (i.e., waddling) and diarrhea. Recovery as judged by external appearance and behaviour was apparent
- Gross pathology:
- Terminal autopsy findings were normal.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Conclusions:
- Under the study conditions, the oral LD50 was found to be >2,723 mg/kg bw active ingredient in rats.
- Executive summary:
A study was conducted to determine the acute oral toxicity of the test substance in CD rats of the Sprague-Dawley derived strain according to OECD Guideline 401. Group of five female and three male fasted rats received a single oral (gavage) dose of 2,723 mg/kg bw active ingredient. Undiluted test substance was administered at a volume of 4.4 mL/kg bw. No mortality occurred and no significant macroscopic abnormalities were seen at necropsy. However, clinical signs were observed (pilo-erection, hunched posture, waddling and diarrhea) in all rats for up to 3 days after treatment. Under the study conditions, the oral LD50 was found to be >2,723 mg/kg bw active ingredient in rats (Kynoch, 1986).
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