1-butylpyrrolidin-2-one

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

08 June 2016 - 17 June 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

Qualifier:

equivalent or similar to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

effusion method: vapour pressure balance

Specific details on test material used for the study:

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature in the dark

TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: before tesing the substance was under vacuum for approximately 54.5 hours.

Key result

Temp.:

25 °C

Vapour pressure:

13 Pa

The values of vapor pressure at 25 °C extrapolated from each graph (Graph of Log10 Vapor Pressure vs Reciprocal Temperature) are summarized in the following table:

Table 11. Summary of Vapor Pressure Data

Run	Logio[Vp(25°C)]
1	0.580
2	0.982
3	0.926
4	1.05
5	1.30
6	1.17
7	1.22
8	1.16
9	1.38
10	1.41
Mean	1.12
Vapor Pressure	13.2 Pa

The test item did not change in appearance under the conditions used in the determination.

Conclusions:

The vapor pressure of the test item has been determined to be 13 Pa at 25 ºC.

Executive summary:

The vapor pressure of N-butylpyrrolidone has been determined to be 13 Pa at 25 °C, using the vapor pressure balance method, designed to be compatible with Method A.4 Vapour Pressure of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 104 of the OECD Guidelines for Testing of Chemicals, 23 March 2006.

Description of key information

The vapour pressure of N-Butylpyrrolidone was determined as 13 Pa at 25 °C.

Key value for chemical safety assessment

Vapour pressure:

13 Pa

at the temperature of:

25 °C

Additional information

The vapor pressure of N-butylpyrrolidone has been determined to be 13 Pa at 25 °C, using the vapor pressure balance method, designed to be compatible with Method A.4 (Regulation (EC) No 440/2008) and OECD test guideline104.

In a disregarded study, the vapour pressure of N-Butylpyrrolidone was determined by the Static method - using a U-tube manometer. The test was conducted in accordance with the procedure described in EU Regulation (EC) 440/2008, Annex Part A, test A.4. The vapour pressure of N-Butylpyrrolidone was detected as 35 Pa (0.35 mbar) at 20 °C. The study is however desregarded because the sample tested was a pre-production sample not representing the final product, and the method used was a less accurate method for low volatility substances.