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Diss Factsheets
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EC number: 614-482-0 | CAS number: 68439-46-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions (non-GLP).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 408 (Repeated Dose 90-Day Oral Toxicity Study in Rodents)
- Deviations:
- yes
- Remarks:
- Urinalysis was not performed.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 68951-67-7
- EC Number:
- 614-831-7
- Cas Number:
- 68951-67-7
- IUPAC Name:
- 68951-67-7
- Details on test material:
- - Name of test material as cited in study report: trade name (C14-15, alcohol, ethoxylated)
- Ethoxylation degree: 7
- Physical state: Liquid
- Analytical purity: 100% a.i.
- Lot/batch No.: Tank 1587
- Storage condition of test material: No data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- As described in guideline.
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- other: plain diet
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- 90 days
- Frequency of treatment:
- Daily
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
0, 300, 1000, 3000, 10,000 ppm
Basis:
nominal in diet
- Remarks:
- Doses / Concentrations:
0, 15, 50, 150, 500 mg/kg bw/d
Basis:
actual ingested
- No. of animals per sex per dose:
- 12
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- As described in guideline.
- Positive control:
- Not required.
Examinations
- Observations and examinations performed and frequency:
- As described in guideline.
- Sacrifice and pathology:
- As described in guideline.
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- effects observed, treatment-related
- Food consumption and compound intake (if feeding study):
- effects observed, treatment-related
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- effects observed, treatment-related
- Clinical biochemistry findings:
- effects observed, treatment-related
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- not examined
- Organ weight findings including organ / body weight ratios:
- effects observed, treatment-related
- Gross pathological findings:
- no effects observed
- Histopathological findings: non-neoplastic:
- no effects observed
- Histopathological findings: neoplastic:
- not examined
- Details on results:
- BODY WEIGHT
Mean body weights of male rats fed 10,000 ppm and of females fed 10,000 and 3000 ppm test substance were significantly lower than control throughout the 13 week feeding study.
FOOD CONSUMPTION
Significantly reduced food intake and increased spillage of the 10,000 ppm diet were observed in both sexes; females fed 3000 ppm diet also had lower food intakes than control but the decrease was significant for only five of the 13 weeks.
HAEMATOLOGY
Haematological alterations observed in 3000 ppm males and in both sexes fed 10,000 ppm test substance were significant increases in total leukocytes and in absolute lymphocyte values. Females fed 10,000 ppm also showed significant depression in numbers of neutrophils (absolute and percent), mean cell volume and mean cell haemoglobin. Males in the upper two treatment groups showed shortened prothrombin times.
CLINICAL CHEMISTRY
Elevated clinical chemical values were, with the exception of plasma urea concentrations, confined to rats in the 10,000 ppm treatment group. Males in this group had significantly higher urea, calcium and potassium values, while females had significantly higher urea, chloride, calcium and cholesterol values. Urea concentrations of females in the 1000 and 3000 ppm groups were also higher than control.
ORGAN WEIGHTS
After correction for reduced terminal body weight, there were increases in mean liver weight in the 3000 and 10,000 ppm groups (both sexes) and in 1000 ppm females. Males fed 10,000 ppm test substance had significantly increased spleen weights and females in the 1000 ppm group had significantly heavier kidneys compared to controls.
Effect levels
- Dose descriptor:
- NOAEL
- Remarks:
- systemic
- Effect level:
- >= 500 mg/kg bw/day (nominal)
- Based on:
- act. ingr.
- Sex:
- male/female
- Basis for effect level:
- other: see 'Remark'
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- No effects on the general health and behaviour of treated rats were evident. Significant treatment-related effects on body weight, food intake, organ weights, clinical chemistry and haematology were identified in one or both sexes at daily doses of 150 and 500 mg/kg bw/d.
Due to the fact that no compound-related gross or histopathological lesions were identified at any dose level, the changes reported are considered minor and not of toxicological significance. Hence, the NOAEL for systemic toxicity was set to greater than 500 mg/kg bw/d.
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