Registration Dossier
Registration Dossier
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EC number: 401-210-9 | CAS number: 83708-14-9 BEHENYLKETENDIMER; HERCULES PMC D-532; PMC D-532
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 015
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- PMC D-532
- IUPAC Name:
- PMC D-532
- Test material form:
- other: waxy solid
Constituent 1
Results and discussion
Any other information on results incl. tables
Physicochemical properties are available for PMC D-532. The water solubility is extremely low< 2x10-16mg/l and the partition coefficient extremely high (log Kow 19.1). The test substance has a low vapour pressure (1.1 Pa@ 1100C) indicating that it is not likely that vapours will reach the nasopharyngeal, tracheobronchial or pulmonary region. In addition, the substance is a waxy solid indicating that particles are not expected to enter respiratory tract and if so, they will most likely deposit in the nasopharyngeal region and subsequently be coughed or sneezed out of the body or swallowed. Subsequent absorption through pores is not likely taking into account the size of the particles. This assumption is also confirmed in 2 skin absorption studies (in vitro and in vivo studies) showing negligible adsorption of the test substance.
(1) Overall, it is concluded that if any PMC D-532 is inhaled absorption is not expected and for risk assessment purposes the inhalation absorption is set at 1%.
(2) The criteria for 10% dermal absorption as given in the REACH guidance (1) (<W > 500 and log Pow > 4) is met – 1% will be used in the risk assessment as realistic worst case estimate based on the available dermal adsorption studies.
(3) Oral adsorption is based on dermal adsorption. Conversion factor used is 1. Hence, for PMC D-532, a worst case adsorption factor of 1% will be used in the risk assessment.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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