Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 237-537-7 | CAS number: 13827-02-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Based on its water-solubility, low molecular weight and the effects observed in rats upon acute oral exposure and acute/ subacute inhalation exposure, the substance is expected to be absorbed by the gastrointestinal and respiratory tract. In the absence of substance-specific data, a default absorption value of 100% is assumed for both routes. Skin penetration of pure potassium trifluorozincate of 0.98% is considered a worst-case situation for workers.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 0.98
- Absorption rate - inhalation (%):
- 100
Additional information
No data is available on the toxicokinetics of potassium trifluorozincate. The substance is water-soluble and will, therefore, readily dissolve into the gastrointestinal fluids. As it has a molecular weight below 200 g/mole (namely, 162 g/mole), it may pass through aqueous pores or be carried through the epithelial barrier by the bulk passage of water. Further, the results of an acute oral toxicity study in rats, in which all three animals administered 2000 mg/kg body weight died (without visible signs of local toxicity), indicate that the substance is absorbed by the gastrointestinal tract. In the absence of substance-specific absorption data, a default (worst case) oral absorption value of 100% is used for DNEL derivation. Upon acute and subacute exposure by inhalation, rats showed local effects in the lungs, indicating deposition of the substance in the lungs. Absorption of deposited substance is expected based on its water-solubility and molecular weight (similar to oral absorption). Moreover, as the systemic toxicity (mortality) observed in the acute oral toxicity study in rats indicated oral absorption, it is likely that the substance will also be absorbed if it is inhaled. In the absence of substance-specific absorption data, a default (worst case) value of 100% for absorption by the inhalation route is used for DNEL derivation.
Dermal absorption
No data is available on the toxicokinetics of potassium trifluorozincate. The results of the acute dermal absorption study, in which Wistar rats were exposed to the test substance indicate that some absorption occurred, but the amount was not determined. Solid substances will only penetrate the skin in (aqueous) solution. Pure potassium trifluorozincate is a salt with a water solubility of 8.2 g/L at neutral pH. Once dissolved, the salt is ionized to its ions Zn2+ , F-, and K+. The ions are hydrophylic and due to lack of lipophilicity, they will not have any affinity to skin(lipids). Therefore, skin absorption can only occur through the water that penetrates the skin and the maximum skin absorption is defined by the maximum water solubility of the salts and the maximum amount of water that can penetrate the skin. The maximum amount of water that can penetrate the skin is determined to be 17 µL per 1 cm2 per 24 hours (Ten Berge, W. A simple dermal absorption model: derivation and application. (Chemosphere 2009; 75(11):1440-5), which equals 6 µL per cm2 per 8 hours. Since 6 µL of water can maximally penetrate 1 cm2 of skin per 8 hours, 6 x 8.2 = 49.2 µg of ionized salt may penetrate 1 cm2 of skin per 8 hours. In an in vitro skin absorption experiment (according to OECD guideline 428), the application should mimic human exposure, normally 1 -5 mg/cm2 (1000 -5000 µg/cm2 ). Thus, in case the skin penetration of pure potassium trifluorozincate would be experimentally determined according to OECD guideline 428 using 5 mg/cm2 as exposure condition, a skin penetration of 0.98% (49.2/5000) would be observed maximally. Therefore a skin penetration of pure potassium trifluorozincate of 0.98% is considered a worse-case situation for workers.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.