Registration Dossier
Registration Dossier
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EC number: 939-479-4 | CAS number: 1471311-60-0
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: gene mutation
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication which meets basic scientific principles.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
- Principles of method if other than guideline:
- Method: other: Woodruff, RC et al., Env. Mutagen., 6, 189-202.
Adult Canton-S males were subjected to a 3 day feeding exposure. They were mated to Basc females using a 2 to 3 day brooding pattern for a total of
three broods spanning 7 days. If the feeding SLRL test were negative, an injection exposure was performed. As in the feeding exposure, a 2 to 3 day brooding pattern for three broods was used. - GLP compliance:
- not specified
- Type of assay:
- Drosophila SLRL assay
Test material
- Reference substance name:
- 1-aminopropan-2-ol
- EC Number:
- 201-162-7
- EC Name:
- 1-aminopropan-2-ol
- Cas Number:
- 78-96-6
- Molecular formula:
- C3H9NO
- IUPAC Name:
- 1-aminopropan-2-ol
- Details on test material:
- - Name of test material (as cited in study report): Mono-isopropanolamine
- Analytical purity: 96.4 %
Constituent 1
Test animals
- Species:
- Drosophila melanogaster
- Strain:
- other: Canton S
- Sex:
- male
Administration / exposure
- Route of administration:
- other: In feed. If the results of the feeding SLRL test were negative, an injection exposure was performed.
- Vehicle:
- no data
- Duration of treatment / exposure:
- feeding study: 3 days; If the results of the feeding SLRL test were negative, a single injection exposure was performed.
- Frequency of treatment:
- continuously in feed.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
feeding study: 24250 ppm, injection: 1940 ppm.
Basis:
- No. of animals per sex per dose:
- no data
- Control animals:
- yes, concurrent no treatment
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- not specified
- Vehicle controls validity:
- valid
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
Any other information on results incl. tables
The test substance was negative in the SLRL-assay.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
Under the conditions tested TEA was not mutagenic in a Drosophila SLRL assay.
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