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Physical & Chemical properties

Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
September 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
Study conducted according to OECD 104 and EU A.4 guidelines, under GLP without deviation and with certificate of analysis included.
Reason / purpose for cross-reference:
reference to other study
Reason / purpose for cross-reference:
reference to same study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
2015-03-05
Type of method:
dynamic method
Remarks:
Knudsen Effusion Method
Test no.:
#1
Temp.:
293.15 K
Vapour pressure:
ca. 10.2 Pa
Remarks on result:
other: First trial
Test no.:
#1
Temp.:
298.15 K
Vapour pressure:
ca. 19.2 Pa
Remarks on result:
other: First trial
Test no.:
#2
Temp.:
293.15 K
Vapour pressure:
ca. 10.5 Pa
Remarks on result:
other: Second trial
Test no.:
#2
Temp.:
298.15 K
Vapour pressure:
ca. 19.4 Pa
Remarks on result:
other: Second trial
Key result
Temp.:
293.15 K
Vapour pressure:
ca. 10.4 Pa
Remarks on result:
other: Mean
Key result
Temp.:
298.15 K
Vapour pressure:
ca. 19.3 Pa
Remarks on result:
other: Mean

First trial:

Mass loss (mg)

Mass loss duration (s)

Vapour pressure (Pa)

Temperature (K)

1/T (K-1)

Log10(p)

1.419

600

13.9342

295.85

3.380E-03

1.1441

1.947

600

19.2029

298.45

3.351E-03

1.2834

4.677

600

46.6127

304.75

3.281E-03

1.6685

10.524

600

106.1009

311.85

3.207E-03

2.0257

21.157

600

215.8842

319.45

3.130E-03

2.3342

A plot of Log10(p) versus reciprocal temperature (1/T) (with p in Pa and T in K) gives the following statistical data using an unweighted least square treatment.

Slope              -4835.7 

Intercept          17.503 

R²                    0.9966

 

The results obtained indicate the following vapour pressure relationship: 

Log10(p (Pa)) = -4835.7 / T (K) + 17.503

 

The above equation yields a vapour pressure of 10.2 Pa at 293.15 K and 19.2 Pa at 298.15 K.

Second trial:

Mass loss (mg)

Mass loss duration (s)

Vapour pressure (Pa)

Temperature (K)

1/T (K-1)

Log10(p)

1.424

600

13.9833

295.85

3.380E-03

1.1456

2.009

600

19.8177

298.55

3.350E-03

1.2971

4.733

600

47.1863

304.95

3.279E-03

1.6738

10.511

600

106.0378

312.25

3.203E-03

2.0255

14.138

600

206.2511

319.95

3.125E-03

2.3144

A plot of Log10(p) versus reciprocal temperature (1/T) (with p in Pa and T in K) gives the following statistical data using an unweighted least square treatment.

Slope              -4648.0

Intercept          16.878 

R²                    0.9953

 

The results obtained indicate the following vapour pressure relationship:

Log10(p (Pa)) = -4648.0/ T (K) + 16.878

 

The above equation yields a vapour pressure of 10.5 Pa at 293.15 K and 19.4 Pa at 298.15 K.

Conclusions:
Using the Knudsen Effusion method according to guideline OECD 104 and method EU A.4, vapour pressure of dihydroterpineol multiconstituent is 10.4 Pa at 20°C and 19.3 Pa at 25°C.
Executive summary:

A study was performed to determine the vapour pressure of test item dihydroterpineol multiconstituent. The method followed was designed to be compliant with the OECD Guideline for Testing of Chemicals No. 104, "Vapour Pressure", adopted in March, 2006 and Regulation (EC) No 761/2009, EC A4, 23 July 2009.

In this dynamic method, the mass of the test substance flowing out per unit of time of a Knudsen cell in the form of vapour, through a micro-orifice under ultra-vacuum conditions was determined at various specified temperatures (from 22 to 47°C). The Hertz-Knudsen equation was used to calculate the vapour pressure corresponding to the mass loss rate.

The Log10(Vapour Pressure (Pa)) was plotted against 1/T (K) and a linear function was obtained. With this equation, the vapour pressure has been calculated for temperatures of 20°C and 25°C.

Two trials were conducted and five points were recorded for each trial.

Log (Vapour Pressure (Pa)) was plotted against reciprocal temperature and values of vapour pressure were calculated at 20°C and 25°C with the linear function parameters (slope and intercept).

Calculated values respect validity criteria (less than 20% of difference) and the linear functions obtained own a correlation coefficient R² over 0.95.

Moreover the calculated values showed good correspondence with the experimentally determined ones.

In conclusion, the vapour pressure of dihydroterpineol multiconstituent is 10.4 Pa at 20°C and 19.3 Pa at 25°C.

Description of key information

The vapour pressure was determined using the Knudsen Effusion method according to guideline OECD 104 and method  EU A.4.

The vapour pressure of dihydroterpineol multiconstituent is 10.4 Pa at 20°C and 19.3 Pa at 25°C.

Key value for chemical safety assessment

Vapour pressure:
10.4 Pa
at the temperature of:
20 °C

Additional information

Key study conducted according to OECD 104 and EU A.4 guidelines. The result is scientifically acceptable and obtained under GLP.

Therefore a reliability of 1 (reliable without restrictions) was assigned.