Registration Dossier
Registration Dossier
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EC number: 223-786-9 | CAS number: 4073-98-7
Endpoint summary
Administrative data
Description of key information
Additional information
No experimental data are available for 4,4'-methylenebis(2,6-xylidine) (CAS 4073 -98 -7). To assess the aquatic toxicity, read across was made to the analogue substances 4,4'-methylenebis(2-methylaniline) (CAS 838 -88 -0) and N,N,N',N'-tetramethyl-4,4'-methylenedianiline (CAS 101 -61 -1).
Short-term toxicity to fish
4,4'-methylenebis(2-methylaniline) (CAS 838 -88 -0):
Not harmful to fish (no mortality up to the maximum water solubility of 16 mg/L; LC50 = 681 mg/L based on nominal concentrations).
N,N,N',N'-tetramethyl-4,4'-methylenedianiline (CAS 101 -61 -1):
Not harmful to fish (no mortality up to the maximum water solubility; LC50 > 100 mg/L based on nominal concentrations).
Long-term toxicity to fish
No data available.
Short-term toxicity to aquatic invertebrates
N,N,N',N'-tetramethyl-4,4'-methylenedianiline (CAS 101 -61 -1):
Acutely very toxic to aquatic invertebrates (48 -h EC50 = 0.531 mg/L, based on the median analytical recovery rate).
Long-term toxicity to aquatic invertebrates
No data available.
Toxicity to aquatic algae
4,4'-methylenebis(2-methylaniline) (CAS 838 -88 -0):
Acutely toxic for aquatic organisms (72 -h ErC50 = 6.104 mg/L, 72 -h ErC10 = 0.260 mg/L, 72 -h NOErC < 0.020 mg/L).
Toxicity to microorganisms
4,4'-methylenebis(2-methylaniline) (CAS 838 -88 -0) and N,N,N',N'-tetramethyl-4,4'-methylenedianiline (CAS 101 -61 -1):
The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriate low concentrations (no inhibitory effects up to the maximum water solubility).
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