Registration Dossier
Registration Dossier
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EC number: 264-431-8 | CAS number: 63721-05-1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Bacterial reverse mutation (Ames test)
A single study conducted according to guideline OECD 471 and under GLP is available (Jones 1988). The study is considered to be relevant, reliable (Klimisch 1) and adequate for the purposes of risk assessment, classification and labeling.
No substantial increase in the incidence of revertant colonies was elicited in strains S. typhimurium TA 100, TA1535, TA 98, TA 1537, TA 1538, and E. coli WP2 uvrA, with and without metabolic activation.
Under the conditions of the assay, no evidence of a mutagenic potential was obtained with the test material.
Short description of key information:
Ames test: negative (non-mutagenic), S. typhimurium TA100, TA1535, TA98, TA1537, TA1538, and E. coli WP2 uvrA, with and without metabolic activation, OECD 471, Jones 1988
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The Jones (1988) study is considered reliable and adequate for the purposes of risk assessment, classification and labeling.
Based on the results of the Jones (1988) study, the substance does not meet the criteria for classification under Directive 2001/59/EC, Annex VI, 4.2.2.3 and under Regulation (EC) No. 1272/2008 Annex I, Part 3, 3.5.2.
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