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Diss Factsheets
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EC number: 700-080-3 | CAS number: 752225-55-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: (EPA) S 163.81-4 "Primary eye irritation study". Federal Register, Vol. 43, No. 163
- Principles of method if other than guideline:
- An excess (0.1 mL) of undiluted substance was instilled into the conjunctival sac of 6 rabbit left eyes.
- GLP compliance:
- no
Test material
- Reference substance name:
- Soybean oil, epoxidized
- EC Number:
- 232-391-0
- EC Name:
- Soybean oil, epoxidized
- Cas Number:
- 8013-07-8
- IUPAC Name:
- 8013-07-8
- Details on test material:
- - Lot/batch No.: prod.Oct.80
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2-3 kg
- Housing: individually in metal cages
- Diet (e.g. ad libitum): ad libitum access to standard rabbit food - NAFAG, No. 814, Gossau SG - and water
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 4 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22±2
- Humidity (%): 55±10
Test system
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL - Observation period (in vivo):
- The eye irritation was appraised with a slit-lamp on day 1, 2, 3, 4, 7, 10 and 14
- Number of animals or in vitro replicates:
- 5
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 1 day
- Max. score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 2 day
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 1 day
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 2 day
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 1day
- Max. score:
- 4.7
- Reversibility:
- fully reversible within: 10 days
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 2 day
- Max. score:
- 3.3
- Reversibility:
- fully reversible within: 10 days
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 3 day
- Max. score:
- 2
- Reversibility:
- fully reversible within: 10 days
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 4 days
- Max. score:
- 1.3
- Reversibility:
- fully reversible within: 10 days
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 7 day
- Max. score:
- 1
- Reversibility:
- fully reversible within: 10 days
Any other information on results incl. tables
Score for eye irritation in rabbits | ||
CORNEA | ||
A | Opacity and degree of density (most dense area scored) | |
No Opacity | 0 | |
Scattered or diffuse area, details of iris clearly visible | 1 | |
Easily discernible translucent areas, details of iris slightly obscured | 2 | |
Opalescent areas, no details of iris visible, size of pupil barely discernible | 3 | |
Opaque, iris invisible | 4 | |
B | Area of cornea involved | 0 |
One quarter (or less) but not zero | 1 | |
Greater than one quarter, but less than half | 2 | |
Greater than half, but less than three quarters .... | 3 | |
Greater than three quarters, up to whole area | 4 | |
A x B X 5 Maximum possible score = 80 | ||
IRIS | ||
A | Normal | 0 |
Folds above normal, congestion, swelling, circumcornea injection (any or all of these or combination of any thereof) iris still reacting to light (sluggish reaction is positive) | 1 | |
No reaction to light, hemorrhage, gross destruction (any or all of these) | 2 | |
A X 5 Maximum possible score =10 | ||
CONJUNCTIVAE | ||
A | Redness (refers to palpebral and bulbar conjunctiva excluding cornea and iris) | |
Vessels normal | 0 | |
Vessels definitely injected above normal | 1 | |
More diffuse, deeper crimson red, individual vessels not easily discernible | 2 | |
Diffuse beefy red | 3 | |
B | Chemosis | |
No swelling | 0 | |
Any swelling above normal (includes nictitating membrane) | 1 | |
Obvious swelling with partial eversion of lids | 2 | |
Swelling with lids about half closed | 3 | |
Swelling with lids about half closed to completely closed | 4 | |
C | Discharge | |
No discharge | 0 | |
Any amount different from normal (does not include small amounts observed in inner canthus of normal animals) | 1 | |
Discharge with moistening of the lids and hairs just adjacent to lids | 2 | |
Discharge with moistening of the lids and hairs, and considerable area around the eye | 3 | |
(A + B + C) x 2 Maximum possible score = 20 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In rabbit eyes no irritation of cornea and iris was observed at any reading. Irritation was seen only in the conjunctiva with a maximum mean score of 4.7 after 24 hours. After 10 days all irritation had disappeared. No symptoms of systemic intoxication were observed throughout the whole test period.
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