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Diss Factsheets
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EC number: 618-295-5 | CAS number: 897626-46-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only short summary available
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Smyth, H.F. Jr. et al.
- Year:
- 1 962
- Bibliographic source:
- Amer Ind Hyg Assoc J 23:95-107
- Reference Type:
- secondary source
- Title:
- Bis(2-ethylhexyl) azelate
- Author:
- OECD
- Year:
- 2 006
- Bibliographic source:
- SIDS Initial Assessment Report for SIAM 22, Paris, France, 18-21 April, 2006
Materials and methods
- Principles of method if other than guideline:
- Primary skin irritation on rabbits was determined on clipped skin after application of the test item or test item solution for 24 h with a 10-grade scale.
- GLP compliance:
- no
Test material
- Reference substance name:
- Bis(2-ethylhexyl) azelate
- EC Number:
- 203-091-7
- EC Name:
- Bis(2-ethylhexyl) azelate
- Cas Number:
- 103-24-2
- Molecular formula:
- C25H48O4
- IUPAC Name:
- bis(2-ethylhexyl) azelate
- Details on test material:
- - Name of test material (as cited in study report): Azelaic acid, di-(2-ethylhexyl) ester
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: albino
Test system
- Type of coverage:
- open
- Preparation of test site:
- other: clipped
- Vehicle:
- other: unchanged (no vehicle) and vehicle (water, propylene glycol or acetone) for testing solutions
- Controls:
- other: not required, untreated sites of the same animal served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.01 mL
- Concentration: 100% or 0.01% solution - Duration of treatment / exposure:
- 24 hours
- Observation period:
- no data
- Number of animals:
- 5
- Details on study design:
- SCORING SYSTEM:
A 10-grade scoring system was used. Grade 1 indicates no irritation and Grade 2 the least visible capillary injection from the undiluted chemical. Grade 6 indicates necrosis when undiluted and Grade 10 indicates necrosis from a 0.01% solution.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: grade of irritation
- Basis:
- mean
- Remarks:
- of all 5 animals
- Time point:
- other: no data
- Score:
- 3
- Max. score:
- 10
- Reversibility:
- no data
- Remarks on result:
- other: The exposure duration was 24 h. The scoring time point is not given.
Any other information on results incl. tables
The test substance had a grade of 3 according to the scoring system, which was applied within this study. However, it is not possible to ransfer these grading scores into Draize scores as required according to OECD guideline 404.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.