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EC number: 219-460-0 | CAS number: 2439-35-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Adequacy of study:
- other information
Data source
Reference
- Title:
- "Combined Repeat Dose and Reproductive/Developmental Toxicity Screening Test of 2-(Dimethylamino)ethyl acrylate|by Oral Administration in Rats"
- Author:
- Ministry of Health and Welfare, Japan
- Year:
- 1 997
- Bibliographic source:
- Toxicity Testing Reports of Environmental Chemicals, vol.5, 583-594
Materials and methods
- Principles of method if other than guideline:
- Method: other: OECD combined repeat dose and reproductive/developmental toxicity screening test
- GLP compliance:
- yes
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- IUCLID4 Test substance: other TS: 99.9 wt% purity, NIPPON SHOKUBAI CO.,LTD. Lot No. 5P07
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Duration of treatment / exposure:
- males; 43 day
females; from 14 day before mating to day 3 of lactation - Frequency of treatment:
- once daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0 (vehicle), 4, 20, 100 mg/kg/day
Basis:
- Control animals:
- other: yes, corn oil
- Details on study design:
- Post-exposure period: 1 day
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 20 mg/kg bw/day (nominal)
- Sex:
- male/female
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
The NOAELs for repeat dose toxicity are considered to be 20
mg/kg/day for both sexes.
- Male:
At 100 mg/kg/day, no death was occured.
- By the observation, transient suppression of body weight gain and decrease in food consumption were observed.
- By the necroscopy findings, thickening of the wall of
the forestomach and enlargement of the pancreatico-duodenal
lymph nodes were observed.
- By the histopathological examination:
Ulceration, inflammatory cell infiltration and
hyperplasia of the mucosa in the forestomach, and hyperplasia of plasma cells in the pancreatioco-duodenal lymph nodes were revealed.
- By the hematological and blood chemical examination:
A increase in reticulocyte, platelet and segmented
neutrophil counts, a decrease in differential lymphocytes counts and albumin were revealed.
At 20 mg/kg/day, similar histopathological changes were
observed in the forestomach.
At 4 mg/kg/day, no effects were observed.
Remark:
Thus the NOEL for males was considered as 4 mg/kg/day.
However, Histopathological changes In forestomach were based on stimulative of 2-(dimethylamino)ethyl acrylate. Then the NOAEL for males was considered as 20 mg/kg/day.
- Female:
At 100 mg/kg/day, 2 females out of 12 died.
- By the observation, a decrease in the absolute thymus
weight was observed.
- By the necroscopy examination, similar changes as males
were observed.
- By the histopathological examination, similar changes as males were observed.
At 20 mg/kg/day and 4 mg/kg/day, no effects were observed.
The result of the hematological and blood chemical
examination in male rats are summarized below.
Dose [mg/kg/day] 0 4 20 100
--------------------------- ---- ---- ---- -----
No. of animals 12 12 12 12
Reticulo (%) 25 27 26 30**
Plt [10E4/ul] 103 103 105 115*
Differential
lymphocytes counts (%) 81 84 82 68**
Differential segmented
neutrophils counts [10E2/ul] 16 12 15 39**
Albumin [g/dl] 3.7 3.8 3.7 3.6*
-------------------------------------------------
significantly different from control: *=p<0.05,**=p<0.01
The major histopathological findings in rats are summarized
below.
Male:
Dose [mg/kg/day] Note 0 4 20 100
------------------------- ---- --- --- --- ----
No. of animals 12 12 12 12
Findings in Lymph node
(pancreatico-duodenal)
-Hyperplasia, plasma cell + # # # 7/7
Finding in forestomach
-Hyperplasia, mucosa + 0 0 2 12**
-Inflam. cell infiltration + 0 0 1 0
++ 0 0 1 11**
-Ulcer + 0 0 0 0
++ 0 0 1 11**
-------------------------------------------------
Note: + slight
++ moderate
# not examined
Female:
Dose [mg/kg/day] Note 0 4 20 100 100
(dead)
------------------------ ---- -- --- -- --- ----
No. of animals 12 12 12 10 2
Findings in Lymph node
(pancreatico-duodenal)
-Hyperplasia, plasma cell + # # # 7/7 #
Finding in forestomach
-Hyperplasia, mucosa ++ 0 0 0 10** 1
-Inflam. cell inifilt ++ 0 0 0 10** 1
-Ulcer ++ 0 0 0 9** 1
--------------------------------------------------
Applicant's summary and conclusion
- Conclusions:
- CL-Freetext:
The NOAEL is considered to be 20 mg/kg/day for both sexes.
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