Registration Dossier
Registration Dossier
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EC number: 202-000-8 | CAS number: 90-51-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October - December 1990
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Data is from experimental study
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- The skin irritation study of test chemical was conducted on single New Zealand White rabbits to assess its skin irritation potential.
- GLP compliance:
- no
Test material
- Reference substance name:
- 6-amino-4-hydroxynaphthalene-2-sulphonic acid
- EC Number:
- 202-000-8
- EC Name:
- 6-amino-4-hydroxynaphthalene-2-sulphonic acid
- Cas Number:
- 90-51-7
- Molecular formula:
- C10H9NO4S
- IUPAC Name:
- 6-amino-4-hydroxynaphthalene-2-sulphonic acid
- Test material form:
- solid
- Details on test material:
- - Name of test material (as cited in study report): 6-amino-4-hydroxynaphthalene-2-sulphonic acid
- Molecular formula : C10H9NO4S
- Molecular weight : 239.26g/mol
- Substance type: Organic
- Physical state: solid
- Purity: No data
- Impurities (identity and concentrations):No data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- other: scarified skin
- Vehicle:
- water
- Controls:
- not required
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 24, 48, 72 hours
- Number of animals:
- 1
- Details on study design:
- - Parameters analysed / observed: hyperemia, edema on intact or scarified skin
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: observation of intact skin
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- other: observation of scarified skin
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- > 1 - < 2
- Remarks on result:
- other: slight congestion, slight edema
- Irritation parameter:
- other: observation of scarified skin
- Basis:
- animal #1
- Time point:
- other: 48/72 h
- Score:
- > 1 - < 2
- Remarks on result:
- other: very weak edema
Applicant's summary and conclusion
- Interpretation of results:
- other: Not irritating
- Conclusions:
- The test chemical was considered to be not irritating to the intact or scarified skin New Zealand White rabbits after exposure of 4 hours.
- Executive summary:
The acute dermal irritation study of test chemical was conducted on New Zealand White rabbit to assess its skin irritation potential.
500mg of chemical was applied for 4 hours and skin was analyzed hyperemia, edema on intact or scarified skin at 24, 48, 72 hours after exposure.
Since the test chemical did not induce any skin reaction, it was considered as not irritating to the intact or scarified skin New Zealand White rabbits after exposure of 4 hours.
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